Contactin 1 Antibody (41): sc-136133

Contactin 1 Antibody (41) is a mouse monoclonal IgG1 antibody that detects Contactin 1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Contactin 1 antibody (41) is available as the non-conjugated format. Contactin 1 plays a critical role in the nervous system, particularly in the formation and maintenance of myelinated axons, which are essential for efficient signal transmission in neurons. Contactin 1 is primarily located at the paranodal regions of myelinated axons, where Contactin 1 interacts with other proteins to facilitate the clustering of voltage-gated sodium channels. This localization is crucial because Contactin 1 ensures proper functioning of action potentials and contributes to overall integrity of the myelin sheath. Disruptions in Contactin 1 function or expression can lead to neurological disorders, highlighting Contactin 1′s importance in maintaining neuronal health and communication. The human Contactin 1 gene encodes a 1,018 amino acid protein, which is part of a larger family of cell adhesion molecules that are vital for synaptic plasticity and neuronal connectivity.

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Contactin 1 Antibody (41) References:

1. Contactin orchestrates assembly of the septate-like junctions at the paranode in myelinated peripheral nerve.  |  Boyle, ME., et al. 2001. Neuron. 30: 385-97. PMID: 11395001
2. Contactin associates with Na+ channels and increases their functional expression.  |  Kazarinova-Noyes, K., et al. 2001. J Neurosci. 21: 7517-25. PMID: 11567041
3. Contactin supports synaptic plasticity associated with hippocampal long-term depression but not potentiation.  |  Murai, KK., et al. 2002. Curr Biol. 12: 181-90. PMID: 11839269
4. Sequence of contactin, a 130-kD glycoprotein concentrated in areas of interneuronal contact, defines a new member of the immunoglobulin supergene family in the nervous system.  |  Ranscht, B. 1988. J Cell Biol. 107: 1561-73. PMID: 3049624
5. Neural cell adhesion molecules in activity-dependent development and synaptic plasticity.  |  Fields, RD. and Itoh, K. 1996. Trends Neurosci. 19: 473-80. PMID: 8931273

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Contactin 1 Antibody (41) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-Contactin 1 Antibody (41) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Contactin 1 Antibody (41) Specifications

Alternate Product Name: Contactin 1

Product Clone Name: 41

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 77-238

Epitope Target: Contactin 1

Epitope Species: human

Product Reactivity/Detection: Contactin 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for Contactin 1 Antibody (41): N/A