connexin 46 Antibody (C-3): sc-365394
- connexin 46 Antibody (C-3) is a mouse monoclonal IgG1 κ connexin 46 antibody, cited in 8 publications, provided at 200 µg/ml
- raised against amino acids 301-435 mapping at the C-terminus of connexin 46 of human origin
- connexin 46 Antibody (C-3) is recommended for detection of connexin 46 of human origin by WB, IP, IF and ELISA
- Anti-connexin 46 Antibody (C-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for connexin 46 Antibody (C-3) for WB applications. This reagent is now offered in a bundle with connexin 46 Antibody (C-3) (see ordering information below).
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connexin 46 Antibody (C-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects connexin 46 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-connexin 46 antibody (C-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. connexin 46 protein, also known as gap junction protein alpha 3, plays a crucial role in cell communication by forming gap junctions that allow the passage of ions and small molecules between adjacent cells. This intercellular communication is vital for maintaining tissue homeostasis and coordinating cellular responses, particularly in the lens of the eye where connexin 46 is predominantly expressed. Disruption of connexin 46 function can lead to severe consequences, such as the development of cataracts, highlighting connexin 46′s importance in lens transparency and overall eye health. The unique structure of connexin proteins, characterized by four transmembrane α-helical domains and specific extracellular loops, contributes to their ability to form functional channels with distinct properties, which are essential for various physiological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
connexin 46 Antibody (C-3) References:
- The novel mouse connexin39 gene is expressed in developing striated muscle fibers. | von Maltzahn, J., et al. 2004. J Cell Sci. 117: 5381-92. PMID: 15466892
- Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. | Xia, CH., et al. 2006. Development. 133: 2033-40. PMID: 16611690
- Knock-in of alpha3 connexin prevents severe cataracts caused by an alpha8 point mutation. | Xia, CH., et al. 2006. J Cell Sci. 119: 2138-44. PMID: 16687738
- Absence of alpha3 (Cx46) and alpha8 (Cx50) connexins leads to cataracts by affecting lens inner fiber cells. | Xia, CH., et al. 2006. Exp Eye Res. 83: 688-96. PMID: 16696970
- Structural and immunocytochemical alterations in eye lens fiber cells from Cx46 and Cx50 knockout mice. | Dunia, I., et al. 2006. Eur J Cell Biol. 85: 729-52. PMID: 16740340
- Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform. | Tang, Y., et al. 2007. Invest Ophthalmol Vis Sci. 48: 2685-94. PMID: 17525200
- Gap junction communication influences intercellular protein distribution in the lens. | Cheng, C., et al. 2008. Exp Eye Res. 86: 966-74. PMID: 18462719
- Functional analysis of hemichannels and gap-junctional channels formed by connexins 43 and 46. | Hoang, QV., et al. 2010. Mol Vis. 16: 1343-52. PMID: 20664797
- Cardiac conduction is required to preserve cardiac chamber morphology. | Chi, NC., et al. 2010. Proc Natl Acad Sci U S A. 107: 14662-7. PMID: 20675583
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
connexin 46 Antibody (C-3) | sc-365394 | 200 µg/ml | $316.00 | |||
connexin 46 Antibody (C-3): m-IgG1 BP-HRP Bundle | sc-531706 | 200 µg Ab; 20 µg BP | $354.00 | |||
connexin 46 Antibody (C-3) AC | sc-365394 AC | 500 µg/ml, 25% agarose | $416.00 | |||
connexin 46 Antibody (C-3) HRP | sc-365394 HRP | 200 µg/ml | $316.00 | |||
connexin 46 Antibody (C-3) FITC | sc-365394 FITC | 200 µg/ml | $330.00 | |||
connexin 46 Antibody (C-3) PE | sc-365394 PE | 200 µg/ml | $343.00 | |||
connexin 46 Antibody (C-3) Alexa Fluor® 488 | sc-365394 AF488 | 200 µg/ml | $357.00 | |||
connexin 46 Antibody (C-3) Alexa Fluor® 546 | sc-365394 AF546 | 200 µg/ml | $357.00 | |||
connexin 46 Antibody (C-3) Alexa Fluor® 594 | sc-365394 AF594 | 200 µg/ml | $357.00 | |||
connexin 46 Antibody (C-3) Alexa Fluor® 647 | sc-365394 AF647 | 200 µg/ml | $357.00 | |||
connexin 46 Antibody (C-3) Alexa Fluor® 680 | sc-365394 AF680 | 200 µg/ml | $357.00 | |||
connexin 46 Antibody (C-3) Alexa Fluor® 790 | sc-365394 AF790 | 200 µg/ml | $357.00 |