connexin 46 Inhibitors
Connexin 46 inhibitors are a class of chemical compounds that specifically target and inhibit the function of connexin 46, a protein encoded by the GJA3 (gap junction protein alpha 3) gene. Connexin 46 is a member of the connexin family of proteins, which are integral components of gap junctions. These gap junctions are specialized intercellular channels that allow for direct communication between adjacent cells by facilitating the passage of ions, metabolites, and other small molecules. Connexin 46, in particular, is predominantly expressed in the lens of the eye, where it plays a crucial role in maintaining lens transparency and homeostasis. By forming gap junction channels, connexin 46 enables the diffusion of essential nutrients and the removal of metabolic waste products, ensuring proper cellular function within the lens.
Structurally, connexin 46 inhibitors are diverse and can include small molecules or peptides specifically designed to interfere with the assembly, opening, or functioning of connexin 46 channels. These inhibitors can bind to specific sites on the connexin 46 protein, preventing it from forming functional gap junctions or blocking the channels once they are formed. This inhibition can disrupt intercellular communication and alter the homeostatic balance maintained by gap junctions in tissues expressing connexin 46. The study of connexin 46 inhibitors provides valuable insights into the mechanisms of gap junction regulation and the role of connexin 46 in cellular communication and tissue homeostasis. By understanding how these inhibitors affect connexin 46 function, researchers can explore the broader implications of gap junction modulation on cellular processes, including ion transport, metabolic coordination, and overall tissue health. Research into these inhibitors thus contributes to a deeper understanding of the physiological and biochemical pathways influenced by gap junctions and connexin 46 specifically.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
Influences intracellular calcium levels, which can indirectly modulate connexin function. | ||||||
Mefenamic acid | 61-68-7 | sc-205380 sc-205380A | 25 g 100 g | $104.00 $204.00 | 6 | |
Similar to flufenamic acid, can disrupt gap junction communication. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Stereoisomer of quinine, which also inhibits gap junction communication. | ||||||
Carbenoxolone disodium | 7421-40-1 | sc-203868 sc-203868A sc-203868B sc-203868C | 1 g 5 g 10 g 25 g | $45.00 $197.00 $351.00 $759.00 | 1 | |
Carbenoxolone is a glycyrrhetinic acid derivative that inhibits connexin 43 by blocking gap junction intercellular communication. It binds to the connexin proteins and interferes with channel pore formation. Non-specific gap junction blocker. Can inhibit gap junction intercellular communication mediated by connexins. | ||||||
18 β-Glycyrrhetinic Acid | 471-53-4 | sc-205573B sc-205573 sc-205573A sc-205573C sc-205573D | 1 g 5 g 10 g 25 g 100 g | $28.00 $54.00 $85.00 $129.00 $313.00 | 3 | |
Similar to Carbenoxolone, 18α-Glycyrrhetinic Acid is a derivative of glycyrrhetinic acid. It inhibits connexin by blocking the gap junction communication, affecting the channel pore formation. Another non-specific inhibitor of gap junctions. Can reduce gap junction communication involving connexins. | ||||||
1-Heptanol | 111-70-6 | sc-237561 | 100 ml | $111.00 | ||
Heptanol is an aliphatic alcohol that inhibits connexin 43 by blocking gap junction intercellular communication. This non-specific inhibitor affects the lipid bilayer of the cell membrane, disrupting the function of gap junction channels. | ||||||
1-Octanol | 111-87-5 | sc-255858 | 1 ml | $45.00 | ||
Octanol works similarly to Heptanol. It is an aliphatic alcohol that disrupts the lipid bilayer of the cell membrane, thereby inhibiting the function of gap junction channels, including connexin. | ||||||
Quinine | 130-95-0 | sc-212616 sc-212616A sc-212616B sc-212616C sc-212616D | 1 g 5 g 10 g 25 g 50 g | $77.00 $102.00 $163.00 $347.00 $561.00 | 1 | |
Quinine is a natural alkaloid that inhibits connexin. It blocks the gap junction intercellular communication by interacting with the channel pore, preventing the exchange of ions and small molecules. Alkaloid that can inhibit gap junction communication non-specifically. | ||||||
Probenecid | 57-66-9 | sc-202773 sc-202773A sc-202773B sc-202773C | 1 g 5 g 25 g 100 g | $27.00 $38.00 $98.00 $272.00 | 28 | |
Probenecid is a uricosuric agent that can inhibit connexin 43. It blocks the hemichannels, disrupting the intercellular communication. Known to block certain connexin hemichannels and could influence connexin 59 indirectly. | ||||||
Lanthanum(III) chloride | 10099-58-8 | sc-257661 | 10 g | $88.00 | ||
Lanthanum Chloride is a gap junction blocker that inhibits connexin by interacting with the channel pore. It prevents the exchange of ions and other small molecules, disrupting gap junction communication. | ||||||