connexin 31 Antibody (LL8): sc-81803

Connexin 31 Antibody (LL8) is a mouse monoclonal IgG1 kappa light chain antibody that detects connexin 31 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-connexin 31 antibody (LL8) is available as a non-conjugated format. Connexin 31, also known as GJB3, plays a crucial role in cell communication by forming gap junctions that allow the passage of ions and small molecules between adjacent cells, which is essential for maintaining tissue homeostasis and coordinating cellular responses. Connexin 31 is primarily located in the plasma membrane of various tissues, including skin, testis, placenta, cochlea, and developing hindbrain, and in mice, connexin 31 is also found in peripheral auditory nerves. Proper localization of connexin 31 is vital for function, as disruptions in expression or localization can lead to severe consequences, such as non-syndromic sensorineural deafness autosomal dominant type 2 (DFNA2) and erythrokeratodermia variabilis (EVK). These conditions highlight connexin 31′s importance in auditory and skin health, making connexin 31 a significant target for research in understanding gap junction-related pathologies.

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connexin 31 Antibody (LL8) References:

1. Emerging issues of connexin channels: biophysics fills the gap.  |  Harris, AL. 2001. Q Rev Biophys. 34: 325-472. PMID: 11838236
2. Molecular interaction of connexin 30.3 and connexin 31 suggests a dominant-negative mechanism associated with erythrokeratodermia variabilis.  |  Plantard, L., et al. 2003. Hum Mol Genet. 12: 3287-94. PMID: 14583444
3. Intracellular distribution, assembly and effect of disease-associated connexin 31 mutants in HeLa cells.  |  He, LQ., et al. 2005. Acta Biochim Biophys Sin (Shanghai). 37: 547-54. PMID: 16077902
4. Gene expression in bovine embryos derived from oocytes with different developmental competence collected at the defined follicular developmental stage.  |  Nemcova, L., et al. 2006. Theriogenology. 65: 1254-64. PMID: 16169583
5. Clinical and genetic heterogeneity of erythrokeratoderma variabilis.  |  Common, JE., et al. 2005. J Invest Dermatol. 125: 920-7. PMID: 16297190
6. Properties of human connexin 31, which is implicated in hereditary dermatological disease and deafness.  |  Abrams, CK., et al. 2006. Proc Natl Acad Sci U S A. 103: 5213-8. PMID: 16549784
7. Tissue-specific effects of wild-type and mutant connexin 31: a role in neurite outgrowth.  |  Unsworth, HC., et al. 2007. Hum Mol Genet. 16: 165-72. PMID: 17142249
8. The connexin31 F137L mutant mouse as a model for the human skin disease erythrokeratodermia variabilis (EKV).  |  Schnichels, M., et al. 2007. Hum Mol Genet. 16: 1216-24. PMID: 17446259
9. Human cardiac gap junctions: isolation, ultrastructure, and protein composition.  |  Manjunath, CK., et al. 1987. J Mol Cell Cardiol. 19: 131-4. PMID: 3573042

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-connexin 31 Antibody (LL8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-connexin 31 Antibody (LL8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

connexin 31 Antibody (LL8) Specifications

Alternate Product Name: GJB3

Product Clone Name: LL8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-271

Epitope Target: connexin 31

Epitope Species: human

Product Reactivity/Detection: connexin 31

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for connexin 31 Antibody (LL8): N/A