connexin 26 Antibody (P1F5): sc-517456

Connexin 26 Antibody (P1F5) is a mouse monoclonal IgG1 antibody that detects connexin 26 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Connexin 26 plays a crucial role in the formation of gap junctions, which are essential for intercellular communication, allowing the passage of ions and small molecules between adjacent cells. Connexin 26 is predominantly located in the cell membrane of various tissues, including the cochlea, skin, and other epithelial cells, where connexin 26 contributes to maintaining homeostasis and facilitating cellular signaling. Proper functioning of connexin 26 is vital, as mutations in connexin 26 can lead to significant health issues, such as autosomal recessive non-syndromic hearing loss, highlighting connexin 26′s importance in auditory function. The connexin family consists of approximately 20 isoforms, each with unique properties, and specific expression of connexin 26 is critical for normal functioning of gap junctions, as connexin 26 absence or dysfunction can disrupt cellular communication and contribute to various pathological conditions. Anti-connexin 26 antibody (P1F5) is an invaluable tool for researchers studying connexin 26′s role in health and disease, providing insights into function and potential therapeutic targets.

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connexin 26 Antibody (P1F5) References:

1. Connexin-30 deletion analysis in connexin-26 heterozygotes.  |  Stevenson, VA., et al. 2003. Genet Test. 7: 151-4. PMID: 12885339
2. Closing the gap on autosomal dominant connexin-26 and connexin-43 mutants linked to human disease.  |  Laird, DW. 2008. J Biol Chem. 283: 2997-3001. PMID: 18089569
3. Inhibition of connexin 26 by the AMP-activated protein kinase.  |  Alesutan, I., et al. 2011. J Membr Biol. 240: 151-8. PMID: 21400101
4. Screening of connexin 26 in nonsyndromic hearing loss.  |  Moreira, D., et al. 2015. Int Arch Otorhinolaryngol. 19: 30-3. PMID: 25992148
5. Connexin 26 Immunohistochemistry in Temporal Bones With Cochlear Otosclerosis.  |  Miller, ME., et al. 2018. Ann Otol Rhinol Laryngol. 127: 536-542. PMID: 29911391
6. Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy.  |  Kamal, DAM., et al. 2020. In Vivo. 34: 1863-1870. PMID: 32606156
7. The Roles of Connexin 26, 32, and 43 as Prognostic Factors for Gastric Cancer.  |  Kim, EY., et al. 2020. Anticancer Res. 40: 4537-4545. PMID: 32727784
8. Subcellular Localization of Connexin 26 in Cardiomyocytes and in Cardiomyocyte-Derived Extracellular Vesicles.  |  Falleni, A., et al. 2021. Molecules. 26: PMID: 34771134
9. Virally Mediated Connexin 26 Expression in Postnatal Scala Media Significantly and Transiently Preserves Hearing in Connexin 30 Null Mice.  |  Zhang, L., et al. 2022. Front Cell Dev Biol. 10: 900416. PMID: 35573684
10. The Expression of Connexin 26 Regulates the Radiosensitivity of Hepatocellular Carcinoma Cells through a Mitogen-Activated Protein Kinases Signal Pathway.  |  Li, Y., et al. 2022. Int J Mol Sci. 23: PMID: 36498978