COMMD8 Antibody (F-1): sc-373869
- COMMD8 Antibody (F-1) is a mouse monoclonal IgG1 κ COMMD8 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 4-25 at the N-terminus of COMMD8 of human origin
- COMMD8 Antibody (F-1) is recommended for detection of COMMD8 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and bovine and porcine
- Anti-COMMD8 Antibody (F-1) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for COMMD8 Antibody (F-1). This work is in progress.
QUICK LINKS
COMMD8 Antibody (F-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects COMMD8 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). COMMD8 Antibody (F-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. COMMD8, a member of the highly conserved COMMD family, consists of 183 amino acids and is predominantly expressed in the thyroid, where COMMD8 plays a crucial role in cellular processes. COMMD8 is involved in regulating the NFκB signaling pathway, which is essential for controlling immune responses and inflammation. This regulation is vital as NFκB dysregulation can lead to various diseases, including cancer and autoimmune disorders. COMMD8 interacts with other COMMD family members, contributing to a network of protein-protein interactions that facilitate diverse cellular functions, such as copper homeostasis and epithelial sodium channel modulation. COMMD8′s unique properties and specific interactions underscore COMMD8′s importance in maintaining cellular health and responding to physiological stressors.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
COMMD8 Antibody (F-1) References:
- COMMD proteins, a novel family of structural and functional homologs of MURR1. | Burstein, E., et al. 2005. J Biol Chem. 280: 22222-32. PMID: 15799966
- Characterization of COMMD protein-protein interactions in NF-kappaB signalling. | de Bie, P., et al. 2006. Biochem J. 398: 63-71. PMID: 16573520
- COMMD proteins and the control of the NF kappa B pathway. | Maine, GN. and Burstein, E. 2007. Cell Cycle. 6: 672-6. PMID: 17361106
- Increased activity of hypoxia-inducible factor 1 is associated with early embryonic lethality in Commd1 null mice. | van de Sluis, B., et al. 2007. Mol Cell Biol. 27: 4142-56. PMID: 17371845
- COMMD proteins: COMMing to the scene. | Maine, GN. and Burstein, E. 2007. Cell Mol Life Sci. 64: 1997-2005. PMID: 17497243
- COMMD1 expression is controlled by critical residues that determine XIAP binding. | Maine, GN., et al. 2009. Biochem J. 417: 601-9. PMID: 18795889
- COMMD1 forms oligomeric complexes targeted to the endocytic membranes via specific interactions with phosphatidylinositol 4,5-bisphosphate. | Burkhead, JL., et al. 2009. J Biol Chem. 284: 696-707. PMID: 18940794
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
COMMD8 Antibody (F-1) | sc-373869 | 200 µg/ml | $316.00 | |||
COMMD8 Antibody (F-1) AC | sc-373869 AC | 500 µg/ml, 25% agarose | $416.00 | |||
COMMD8 Antibody (F-1) HRP | sc-373869 HRP | 200 µg/ml | $316.00 | |||
COMMD8 Antibody (F-1) FITC | sc-373869 FITC | 200 µg/ml | $330.00 | |||
COMMD8 Antibody (F-1) PE | sc-373869 PE | 200 µg/ml | $343.00 | |||
COMMD8 Antibody (F-1) Alexa Fluor® 488 | sc-373869 AF488 | 200 µg/ml | $357.00 | |||
COMMD8 Antibody (F-1) Alexa Fluor® 546 | sc-373869 AF546 | 200 µg/ml | $357.00 | |||
COMMD8 Antibody (F-1) Alexa Fluor® 594 | sc-373869 AF594 | 200 µg/ml | $357.00 | |||
COMMD8 Antibody (F-1) Alexa Fluor® 647 | sc-373869 AF647 | 200 µg/ml | $357.00 | |||
COMMD8 Antibody (F-1) Alexa Fluor® 680 | sc-373869 AF680 | 200 µg/ml | $357.00 | |||
COMMD8 Antibody (F-1) Alexa Fluor® 790 | sc-373869 AF790 | 200 µg/ml | $357.00 | |||
COMMD8 (F-1) Neutralizing Peptide | sc-373869 P | 100 µg/0.5 ml | $68.00 |