Cochlioquinone B, the minor component of a bioactive pigment isolated from Bipolaris leersia, is an NADH ubiquinonereductase inhibitor and a phytotoxic agent inhibiting root growth. It is closely related to Cochlioquinone A that inhibits diacylglycerol acyltransferase and exhibits anti-angiogenic and nematocidal activity. Cochlioquinones have recently been shown to be antagonists of the human chemokine receptor, CCR5, in HIV-1.
1. Jung, H.J., et al. 2003. Bioorg. Med. Chem. 11: 4743-4747. PMID: 14556789
2. Lee, H.B., et al. 2003. J. Antibiot. 56: 967-969. PMID: 14763563
3. Yoganathan, K., et al, 2004. J. Antibiot. 57: 59-63. PMID: 1503248
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