DGAT Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amidepsine A | 169181-28-6 | sc-221244 sc-221244A | 1 mg 2.5 mg | $257.00 $497.00 | ||
Amidepsine A functions as a potent diacylglycerol acyltransferase (DGAT) inhibitor, characterized by its ability to modulate lipid metabolism. Its unique molecular structure facilitates specific interactions with the enzyme's active site, altering substrate binding dynamics. The compound exhibits distinctive reaction kinetics, demonstrating a competitive inhibition profile that influences triglyceride synthesis pathways. This modulation can lead to significant alterations in lipid droplet formation and cellular energy homeostasis. | ||||||
Xanthohumol from hop (Humulus lupulus) | 6754-58-1 | sc-301982 | 5 mg | $354.00 | 1 | |
Xanthohumol, derived from hops, acts as a diacylglycerol acyltransferase (DGAT) modulator, showcasing unique interactions with lipid metabolic pathways. Its structure allows for selective binding to DGAT, influencing enzyme conformation and substrate accessibility. This compound exhibits non-competitive inhibition, impacting triglyceride synthesis rates and altering lipid droplet dynamics. Additionally, Xanthohumol's hydrophobic properties enhance its interaction with membrane-associated enzymes, further influencing lipid metabolism. | ||||||
Cochlioquinone A | 32450-25-2 | sc-202109 | 500 µg | $291.00 | 1 | |
Cochlioquinone A functions as a diacylglycerol acyltransferase (DGAT) with distinctive molecular characteristics that facilitate its role in lipid metabolism. Its unique structural features enable it to engage in specific hydrogen bonding and hydrophobic interactions with the enzyme's active site, modulating catalytic efficiency. This compound exhibits a substrate-dependent kinetic profile, influencing the rate of triglyceride formation and altering lipid droplet morphology through its dynamic interactions with cellular membranes. | ||||||
Cochlioquinone B | 32450-26-3 | sc-202110 | 500 µg | $246.00 | ||
Cochlioquinone B acts as a diacylglycerol acyltransferase (DGAT), showcasing unique binding affinities that enhance its catalytic role in lipid biosynthesis. Its structural conformation allows for selective interactions with acyl-CoA substrates, promoting efficient esterification processes. The compound's distinct hydrophobic regions contribute to its ability to stabilize lipid bilayers, influencing membrane fluidity and integrity, while its reaction kinetics reveal a complex interplay with various lipid species, impacting overall metabolic pathways. | ||||||
Amidepsine D | 79786-34-8 | sc-221245 sc-221245A | 1 mg 2.5 mg | $267.00 $543.00 | ||
Amidepsine D functions as a diacylglycerol acyltransferase (DGAT), exhibiting remarkable specificity in substrate recognition that facilitates lipid assembly. Its unique molecular architecture enables effective interactions with both diacylglycerol and acyl-CoA, driving rapid acylation reactions. The compound's hydrophilic and hydrophobic domains create a dynamic environment that modulates enzyme activity, influencing lipid droplet formation and cellular energy storage pathways. | ||||||
A 922500 | 959122-11-3 | sc-203793 | 10 mg | $265.00 | 2 | |
A 922500 acts as a diacylglycerol acyltransferase (DGAT), characterized by its intricate binding dynamics with lipid substrates. Its structural features promote selective acylation, enhancing the efficiency of lipid synthesis. The compound's unique conformational flexibility allows it to adapt during catalysis, optimizing reaction kinetics. Additionally, its amphipathic nature influences membrane interactions, playing a crucial role in lipid droplet biogenesis and metabolic regulation. | ||||||