CNOT11 Antibody (C-6): sc-377068

CNOT11 Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects CNOT11 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-CNOT11 antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CNOT11, also known as CCR4-NOT transcription complex, subunit 11, plays a crucial role in the CCR4-NOT complex, which is essential for regulating gene expression and mRNA degradation. This complex is involved in various cellular processes, including the modulation of nuclear hormone receptor activities and the regulation of histone modifications, particularly Histone H3 lysine 4 methylation, through a ubiquitin-dependent pathway that likely engages the proteasome. CNOT11 consists of 510 amino acids and forms a subcomplex with CNOT10, which is docked to the CNOT1 scaffold, highlighting its integral role in the larger CCR4-NOT complex. The gene encoding CNOT11 is located on human chromosome 2q11.2, a region that is significant due to its size and gene density, comprising approximately 8% of the human genome and containing over 1,400 genes. Understanding the function and interactions of CNOT11 is vital for elucidating its contributions to cellular regulation and potential implications in various diseases.

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CNOT11 Antibody (C-6) References:

1. The human POP2 gene: identification, sequencing, and mapping to the critical region of the 5q- syndrome.  |  Fidler, C., et al. 1999. Genomics. 56: 134-6. PMID: 10036195
2. Isolation and characterization of human orthologs of yeast CCR4-NOT complex subunits.  |  Albert, TK., et al. 2000. Nucleic Acids Res. 28: 809-17. PMID: 10637334
3. Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.  |  Prévôt, D., et al. 2001. J Biol Chem. 276: 9640-8. PMID: 11136725
4. BTG2 antiproliferative protein interacts with the human CCR4 complex existing in vivo in three cell-cycle-regulated forms.  |  Morel, AP., et al. 2003. J Cell Sci. 116: 2929-36. PMID: 12771185
5. Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation.  |  Dorfleutner, A., et al. 2007. Infect Immun. 75: 1484-92. PMID: 17178784
6. Human carbon catabolite repressor protein (CCR4)-associative factor 1: cloning, expression and characterization of its interaction with the B-cell translocation protein BTG1.  |  Bogdan, JA., et al. 1998. Biochem J. 336 (Pt 2): 471-81. PMID: 9820826

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CNOT11 Antibody (C-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-CNOT11 Antibody (C-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CNOT11 Antibody (C-6) Specifications

Alternate Product Name: CNOT11

Product Clone Name: C-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 227-261

Epitope Target: CNOT11

Epitope Species: human

Product Reactivity/Detection: CNOT11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: canine, porcine and avian

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for CNOT11 Antibody (C-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin