CMV pp65 Antibody (1-L-11): sc-52401

CMV pp65 Antibody (1-L-11) is a mouse monoclonal IgG1 antibody that detects CMV pp65 protein of CMV origin by western blotting (WB) and immunofluorescence (IF). Anti-CMV pp65 antibody (1-L-11) is available as the non-conjugated format. Cytomegalovirus (CMV), also known as human herpesvirus 5 (HHV-5), is a member of the herpes virus family, which includes other notable viruses such as herpes simplex virus types 1 and 2, Varicella Zoster Virus, and Epstein Barr virus. These viruses can remain dormant in the body for extended periods, posing significant health risks, particularly to immunocompromised individuals. CMV pp65 protein plays a crucial role in the viral life cycle as a major component of the CMV virion, contributing to viral structural integrity and functionality. CMV pp65 is essential during the lytic phase of infection, where abundant synthesis serves as a target for robust CD8(+) T cell response, vital for controlling CMV infection. Understanding CMV pp65 function is important not only for elucidating CMV pathogenesis mechanisms but also for developing targeted therapies and vaccines against this virus, particularly in vulnerable populations.

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CMV pp65 Antibody (1-L-11) References:

1. Antisense oligonucleotide ISIS 2922 targets IE-expression and prevents HCMV-IE-induced suppression of TSP-1 and TSP-2 expression.  |  Margraf, S., et al. 2001. Nucleosides Nucleotides Nucleic Acids. 20: 1425-8. PMID: 11563036
2. Kinetics of HCMV immediate early mRNA expression in stably transfected fibroblasts.  |  Snaar, SP., et al. 2002. J Cell Sci. 115: 321-8. PMID: 11839784
3. Comparative analysis of CD8+ T cell responses against human cytomegalovirus proteins pp65 and immediate early 1 shows similarities in precursor frequency, oligoclonality, and phenotype.  |  Khan, N., et al. 2002. J Infect Dis. 185: 1025-34. PMID: 11930311
4. Comparison of hCMV immediate early and CaMV 35S promoters in both plant and human cells.  |  Vlasák, J., et al. 2003. J Biotechnol. 103: 197-202. PMID: 12890606
5. CD8(+) T-cell immunity to cytomegalovirus.  |  Moss, P. and Khan, N. 2004. Hum Immunol. 65: 456-64. PMID: 15172445
6. Molecular, biological, and in vivo characterization of the guinea pig cytomegalovirus (CMV) homologs of the human CMV matrix proteins pp71 (UL82) and pp65 (UL83).  |  McGregor, A., et al. 2004. J Virol. 78: 9872-89. PMID: 15331722
7. Simultaneous generation of cytomegalovirus-specific CD8+ and CD4+ T lymphocytes by use of dendritic cells comodified with pp65 mRNA and pp65 protein.  |  Carlsson, B., et al. 2005. J Infect Dis. 192: 1912-20. PMID: 16267762
8. Comparison of HCMV IE and EF-1 promoters for the stable expression of beta-subunit of hexosaminidase in CHO cell lines.  |  Sinici, I., et al. 2006. Biochem Genet. 44: 173-80. PMID: 16645900
9. Antibodies to human cytomegalovirus protein UL83 in systemic sclerosis.  |  Namboodiri, AM., et al. 2006. Clin Exp Rheumatol. 24: 176-8. PMID: 16762154

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CMV pp65 Antibody (1-L-11) has 17 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CMV pp65 Antibody (1-L-11) Specifications

Alternate Product Name: CMV pp65

Product Clone Name: 1-L-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CMV pp65

Epitope Species: CMV

Product Reactivity/Detection: pp65

Species Reactivity/Detection: CMV

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for CMV pp65 Antibody (1-L-11): N/A