CMTM5 Antibody (A-11): sc-374206
- CMTM5 Antibody (A-11) is a mouse monoclonal IgG1 κ CMTM5 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 199-221 at the C-terminus of CMTM5 of human origin
- CMTM5 Antibody (A-11) is recommended for detection of CMTM5 isoforms 1-5 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CMTM5 Antibody (A-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CMTM5 Antibody (A-11) for WB and IHC(P) applications. These reagents are now offered in bundles with CMTM5 Antibody (A-11) (see ordering information below).
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CMTM5 Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects CMTM5 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-CMTM5 antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CMTM5, also known as CKLF-like MARVEL transmembrane domain containing 5, is a 223 amino acid multi-pass membrane protein that plays a crucial role in cellular processes, particularly in inducing apoptosis in various carcinoma cells through a caspase-dependent pathway. This function positions CMTM5 as a potential tumor suppressor, linking CMTM5 to cancer biology and therapeutic strategies. CMTM5 is predominantly expressed in brain tissue and contains a MARVEL domain, essential for structural integrity and function. Alternative splicing of CMTM5 gene results in five isoforms, with major variant CMTM5-v1 being broadly expressed in human fetal and adult tissues, yet largely absent in many carcinoma cell lines. CMTM5 gene is located on human chromosome 14q11.2, a region associated with various cancers, highlighting CMTM5′s potential relevance in cancer research and treatment.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CMTM5 Antibody (A-11) References:
- Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation. | Han, W., et al. 2003. Genomics. 81: 609-17. PMID: 12782130
- CMTM5 exhibits tumor suppressor activities and is frequently silenced by methylation in carcinoma cell lines. | Shao, L., et al. 2007. Clin Cancer Res. 13: 5756-62. PMID: 17908965
- CMTM3 can affect the transcription activity of androgen receptor and inhibit the expression level of PSA in LNCaP cells. | Wang, Y., et al. 2008. Biochem Biophys Res Commun. 371: 54-8. PMID: 18402773
- CMTM5-v1 induces apoptosis in cervical carcinoma cells. | Shao, L., et al. 2009. Biochem Biophys Res Commun. 379: 866-71. PMID: 19124004
- CMTM5 induces apoptosis of pancreatic cancer cells and has synergistic effects with TNF-alpha. | Guo, X., et al. 2009. Biochem Biophys Res Commun. 387: 139-42. PMID: 19577543
- New members of the chemokine receptor gene family. | Raport, CJ., et al. 1996. J Leukoc Biol. 59: 18-23. PMID: 8558062
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CMTM5 Antibody (A-11) | sc-374206 | 200 µg/ml | $316.00 | |||
CMTM5 Antibody (A-11): m-IgG Fc BP-HRP Bundle | sc-527444 | 200 µg Ab; 10 µg BP | $354.00 | |||
CMTM5 Antibody (A-11): m-IgG1 BP-HRP Bundle | sc-532817 | 200 µg Ab; 20 µg BP | $354.00 | |||
CMTM5 Antibody (A-11) AC | sc-374206 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CMTM5 Antibody (A-11) HRP | sc-374206 HRP | 200 µg/ml | $316.00 | |||
CMTM5 Antibody (A-11) FITC | sc-374206 FITC | 200 µg/ml | $330.00 | |||
CMTM5 Antibody (A-11) PE | sc-374206 PE | 200 µg/ml | $343.00 | |||
CMTM5 Antibody (A-11) Alexa Fluor® 488 | sc-374206 AF488 | 200 µg/ml | $357.00 | |||
CMTM5 Antibody (A-11) Alexa Fluor® 546 | sc-374206 AF546 | 200 µg/ml | $357.00 | |||
CMTM5 Antibody (A-11) Alexa Fluor® 594 | sc-374206 AF594 | 200 µg/ml | $357.00 | |||
CMTM5 Antibody (A-11) Alexa Fluor® 647 | sc-374206 AF647 | 200 µg/ml | $357.00 | |||
CMTM5 Antibody (A-11) Alexa Fluor® 680 | sc-374206 AF680 | 200 µg/ml | $357.00 | |||
CMTM5 Antibody (A-11) Alexa Fluor® 790 | sc-374206 AF790 | 200 µg/ml | $357.00 | |||
CMTM5 (A-11) Neutralizing Peptide | sc-374206 P | 100 µg/0.5 ml | $68.00 |