CMC1 Antibody (A-3): sc-398483

CMC1 Antibody (A-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects CMC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CMC1 Antibody (A-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CMC1, also known as COX assembly mitochondrial protein 1 homolog, consists of 106 amino acids and is primarily localized to the mitochondrion, where CMC1 plays a crucial role in the assembly of cytochrome c oxidase (COX), an essential component of the mitochondrial respiratory chain. This assembly is vital for cellular respiration and energy production, as COX is responsible for the reduction of oxygen to water, a key step in the electron transport chain. Additionally, CMC1 binds copper, suggesting CMC1′s involvement in the trafficking of copper to COX and superoxide dismutase 1 (SOD1), which are critical for maintaining mitochondrial function and protecting against oxidative stress. CMC1 gene is conserved across various species, including chimpanzees, dogs, cows, mice, chickens, zebrafish, fruit flies, and mosquitoes, and is located on human chromosome 3p24.1, a region associated with several genetic diseases and important tumor suppressor genes.

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CMC1 Antibody (A-3) References:

1. Genomic structure and paralogous regions of the inversion breakpoint occurring between human chromosome 3p12.3 and orangutan chromosome 2.  |  Yue, Y., et al. 2005. Cytogenet Genome Res. 108: 98-105. PMID: 15545721
2. Comparative cytogenetics of human chromosome 3q21.3 reveals a hot spot for ectopic recombination in hominoid evolution.  |  Yue, Y., et al. 2005. Genomics. 85: 36-47. PMID: 15607420
3. Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the 'elimination test'.  |  Darai, E., et al. 2005. Genomics. 86: 1-12. PMID: 15913951
4. The DNA sequence, annotation and analysis of human chromosome 3.  |  Muzny, DM., et al. 2006. Nature. 440: 1194-8. PMID: 16641997
5. Establishment and characterization of two uveal melanoma cell lines derived from tumors with loss of one chromosome 3.  |  Nareyeck, G., et al. 2006. Exp Eye Res. 83: 858-64. PMID: 16750193
6. Cmc1p is a conserved mitochondrial twin CX9C protein involved in cytochrome c oxidase biogenesis.  |  Horn, D., et al. 2008. Mol Cell Biol. 28: 4354-64. PMID: 18443040
7. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.  |  Hendrickson, SL., et al. 2010. PLoS One. 5: e12862. PMID: 20877624

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CMC1 Antibody (A-3) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CMC1 Antibody (A-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CMC1 Antibody (A-3) Specifications

Alternate Product Name: CMC1

Product Clone Name: A-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 1-106

Epitope Target: CMC1

Epitope Species: human

Product Reactivity/Detection: CMC1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CMC1 Antibody (A-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin