Clostridium difficile Toxin A Antibody (5155): sc-58109
- Clostridium difficile Toxin A Antibody (5155) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against Clostridium difficile
- recommended for detection of toxin A of Clostridium difficile origin by ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Clostridium difficile Toxin A Antibody (5155). This work is in progress.
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Clostridium difficile Toxin A Antibody (5155) is a mouse monoclonal IgG1 antibody that detects Clostridium difficile Toxin A by enzyme-linked immunosorbent assay (ELISA). Clostridium difficile Toxin A is a critical virulence factor in the pathogenesis of Clostridium difficile infections, primarily responsible for severe inflammatory diarrhea associated with antibiotic-associated colitis. Clostridium difficile Toxin A (5155) antibody recognizes a protein composed of 39 repetitive units that facilitate binding to specific carbohydrates on intestinal epithelial cell surfaces, essential for pathogenicity. Once bound, Clostridium difficile Toxin A exerts effects by inducing significant apoptosis in colonocytes, contributing to ulcer formation and pseudomembranes in the intestinal lining. This apoptotic pathway involves p38 mitogen-activated protein kinase-dependent activation of p53, leading to p21 induction, which results in cytochrome c release and caspase-3 activation through Bak activation. Anti-Clostridium difficile Toxin A antibody (5155) serves as an invaluable tool for researchers studying this pathogen and its associated diseases, particularly given the protein′s role in disrupting cellular integrity and promoting cell death.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clostridium difficile Toxin A Antibody (5155) | sc-58109 | 100 µg/ml | $322.00 |