Date published: 2026-3-17

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Clopidogrel sulfate (CAS 135046-48-9)

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Alternate Names:
Methyl (2S)-(2-chlorophenyl)(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate sulfate
Application:
Clopidogrel sulfate is an irreversible inhibitor of P2Y12
CAS Number:
135046-48-9
Purity:
≥97%
Molecular Weight:
419.89
Molecular Formula:
C16H16ClNO2S•H2SO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Clopidogrel sulfate is a compound that functions as an antiplatelet agent. It inhibits the platelet aggregation by irreversibly binding to the P2Y12 receptor on platelets, preventing the activation of the glycoprotein IIb/IIIa complex. This binding inhibits the final common pathway for platelet aggregation, reducing the risk of thrombosis. At the molecular level, Clopidogrel sulfate undergoes a two-step metabolic activation process, ultimately producing an active metabolite that interacts with the P2Y12 receptor. This interaction blocks the ADP-mediated activation of the glycoprotein IIb/IIIa complex, thereby inhibiting platelet aggregation. In experimental applications, Clopidogrel sulfate′s mechanism of action involves interfering with the ADP-mediated activation of platelets, ultimately reducing the risk of thrombotic events.


Clopidogrel sulfate (CAS 135046-48-9) References

  1. Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS-induced systemic inflammation in a rat model.  |  Hagiwara, S., et al. 2011. Shock. 35: 289-92. PMID: 20720514
  2. Direct vasoactive properties of thienopyridine-derived nitrosothiols.  |  Bundhoo, SS., et al. 2011. J Cardiovasc Pharmacol. 58: 550-8. PMID: 21822146
  3. Adenosine diphosphate receptor antagonist clopidogrel sulfate attenuates LPS-induced systemic inflammation in a rat model.  |  Winning, J., et al. 2011. Shock. 36: 317; author reply 317-8. PMID: 21844789
  4. Safety of early laparoscopic cholecystectomy for patients with acute cholecystitis undergoing antiplatelet or anticoagulation therapy: a single-institution experience.  |  Noda, T., et al. 2014. Hepatogastroenterology. 61: 1501-6. PMID: 25436333
  5. Failure of Nonoperative Management following Angioembolization for Blunt Splenic and Pancreatic Tail Injury.  |  Nishida, K. and Kubota, T. 2020. Case Rep Emerg Med. 2020: 8863885. PMID: 33178466
  6. Drug-induced hypersensitivity syndrome caused by minodronic acid hydrate.  |  Muto, Y., et al. 2021. BMC Pulm Med. 21: 350. PMID: 34743720
  7. The effects of antithrombotic therapy in ab interno trabeculotomy with a spatula-shaped microhook.  |  Kanda, S., et al. 2022. PLoS One. 17: e0262548. PMID: 35025952
  8. Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota.  |  Ma, SR., et al. 2022. Signal Transduct Target Ther. 7: 207. PMID: 35794102
  9. A feces-filled non-inverted ileal pseudodiverticulum presenting as a pedunculated polyp successfully treated by traction-assisted endoscopic submucosal dissection.  |  Inada, T., et al. 2023. DEN Open. 3: e139. PMID: 35898827
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Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Clopidogrel sulfate, 500 mg

sc-337638A
500 mg
$67.00

Clopidogrel sulfate, 1 g

sc-337638
1 g
$142.00