CLIP-170 Antibody (E-8) is a mouse monoclonal IgG3 (kappa light chain) provided at 200 µg/ml
specific for an epitope mapping between amino acids 6-23 at the N-terminus of CLIP-170 of human origin
recommended for detection of CLIP-170 and restin of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and bovine
See CLIP-170 (F-3): sc-28325 for CLIP-170 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
m-IgG3 BP-HRP is the preferred secondary detection reagent for CLIP-170 Antibody (E-8) for WB applications. This reagent is now offered in a bundle with CLIP-170 Antibody (E-8) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Cytoplasmic linker protein (CLIP-170) is the original member of a group of microtuble binding proteins designated as plus-end-binding proteins (+TIPs). CLIP-170 binds to the growing plus ends of microtubules and acts as a linker between the dynamic microtubule ends and organelle membranes. The protein acts as an anticatastrophic factor, promoting microtubule rescue near the cell periphery. Fluorescently labeled CLIP-170 can be visualized as a comet like streak around the growing ends of microtubules. CLIP-170 co-localizes with Dynactin and Dynein at microtubule ends and also at the kinetochore. Restin, first identified as a marker for Hodgkin and Reed-Sternberg (HRS) cells, is a splice variant of the gene that includes a 35 amino acid stretch not present in CLIP-170. CLIP-170/restin is highly expressed in HRS cells, monocyte-derived dendritic cells, IL-4 + CD40L activated B cells and Ki-1 lymphoma.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.