CLIM-1/2 Antibody (C-4): sc-373985
- CLIM-1/2 Antibody (C-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of CLIM-1 of human origin
- recommended for detection of CLIM-1 and CLIM-2 of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-373985 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CLIM-1/2 Antibody (C-4). This work is in progress.
CLIM-1/2 Antibody (C-4) is a mouse monoclonal IgG1 antibody that detects CLIM-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CLIM-1, also known as LIM domain-binding factor-2, plays a crucial role in cellular signaling and gene regulation by interacting with various transcription factors, thereby influencing transcriptional activity of target genes. CLIM-1 is primarily located in the cytoplasm, where CLIM-1 is involved in assembling transcriptional complexes essential for muscle development and function. Northern blot analysis reveals a predominant 2.0-kb transcript in heart and skeletal muscle, underscoring CLIM-1′s importance in muscle physiology. CLIM-1 interacts with alpha-actinin-2, a key component of the cytoskeleton, through its LIM domain, facilitating CLIM-1 localization to actin stress fibers in nonmuscle cells. This interaction highlights CLIM-1′s structural significance and role in maintaining cellular integrity and function. With an ability to form complexes that regulate gene expression, CLIM-1 is vital for various biological processes, making CLIM-1/2 (C-4) antibody an essential tool for researchers studying muscle biology and transcriptional regulation.
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CLIM-1/2 Antibody (C-4) References:
- The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration. | Storbeck, CJ., et al. 2009. Mol Biol Cell. 20: 4174-82. PMID: 19675209
- Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis. | Shang, MM., et al. 2014. Arterioscler Thromb Vasc Biol. 34: 2068-77. PMID: 24925974
- Compensatory Actions of Ldb Adaptor Proteins During Corticospinal Motor Neuron Differentiation. | Leone, DP., et al. 2017. Cereb Cortex. 27: 1686-1699. PMID: 26830346
- The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis. | Gueta, K., et al. 2016. Development. 143: 4182-4192. PMID: 27697904
- LDB2 regulates the expression of DLL4 through the formation of oligomeric complexes in endothelial cells. | Choi, HJ., et al. 2018. BMB Rep. 51: 21-26. PMID: 28946938
- LDB2 inhibits proliferation and migration in liver cancer cells by abrogating HEY1 expression. | Yu, H., et al. 2017. Oncotarget. 8: 94440-94449. PMID: 29212240
- Cooperation of LIM domain-binding 2 (LDB2) with EGR in the pathogenesis of schizophrenia. | Ohnishi, T., et al. 2021. EMBO Mol Med. 13: e12574. PMID: 33656268
- LIM-domain binding protein 2 was down-regulated by miRNA-96-5p inhibited the proliferation, invasion and metastasis of lung cancer H1299 cells. | Chu, F., et al. 2023. Clinics (Sao Paulo). 78: 100145. PMID: 36473369
- Serum methylation of GALNT9, UPF3A, WARS, and LDB2 as noninvasive biomarkers for the early detection of colorectal cancer and advanced adenomas. | Gallardo-Gómez, M., et al. 2023. Clin Epigenetics. 15: 157. PMID: 37794510
- Interactions between LIM domains and the LIM domain-binding protein Ldb1. | Breen, JJ., et al. 1998. J Biol Chem. 273: 4712-7. PMID: 9468533
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLIM-1/2 Antibody (C-4) | sc-373985 | 200 µg/ml | $322.00 | |||
CLIM-1/2 Antibody (C-4) X | sc-373985 X | 200 µg/0.1 ml | $322.00 |