CLIC1 Antibody (F-9): sc-374202
- CLIC1 Antibody (F-9) is a mouse monoclonal IgG2b κ CLIC1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 194-241 mapping at the C-terminus of CLIC1 of human origin
- CLIC1 Antibody (F-9) is recommended for detection of CLIC1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CLIC1 Antibody (F-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for CLIC1 Antibody (F-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with CLIC1 Antibody (F-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
CLIC1 Antibody (F-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects CLIC1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CLIC1 Antibody (F-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Chloride intracellular channel 1 (CLIC1), also known as NCC27, is a crucial member of a highly conserved family of chloride ion channels that can exist in both soluble and integral membrane forms. CLIC1′s unique structure includes a redox-active site akin to glutaredoxin, allowing CLIC1 to function as an anion-selective channel. Notably, CLIC1 can form dimers when oxidized, enabling the creation of chloride ion channels in bilayers and vesicles, while a reducing environment inhibits this process. Insulin influences CLIC1 regulation, potentially inducing subnuclear relocalization. CLIC1 plays a role in macrophage activation, and CLIC1 downregulation prevents tumor necrosis factor-alpha release induced by β-Amyloid protein stimulation, highlighting CLIC1′s potential role in neurodegenerative diseases such as Alzheimer′s disease, where β-Amyloid accumulation is a hallmark.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CLIC1 Antibody (F-9) References:
- CLIC1 functional expression is required for cAMP-induced neurite elongation in post-natal mouse retinal ganglion cells. | Averaimo, S., et al. 2014. J Neurochem. 131: 444-56. PMID: 25060644
- Relocation of CLIC1 promotes tumor cell invasion and colonization of fibrin. | Gurski, LA., et al. 2015. Mol Cancer Res. 13: 273-80. PMID: 25205595
- CLIC1 overexpression is associated with poor prognosis in gallbladder cancer. | Ding, Q., et al. 2015. Tumour Biol. 36: 193-8. PMID: 25227665
- CLIC1 Induces Drug Resistance in Human Choriocarcinoma Through Positive Regulation of MRP1. | Wu, J. and Wang, D. 2017. Oncol Res. 25: 863-871. PMID: 27983917
- MtHsp70-CLIC1-pulsed dendritic cells enhance the immune response against ovarian cancer. | Yu, W., et al. 2017. Biochem Biophys Res Commun. 494: 13-19. PMID: 29061300
- CLIC1 promotes the progression of oral squamous cell carcinoma via integrins/ERK pathways. | Feng, J., et al. 2019. Am J Transl Res. 11: 557-571. PMID: 30899362
- CLIC1 knockout inhibits invasion and migration of gastric cancer by upregulating AMOT-p130 expression. | Qiu, Y., et al. 2021. Clin Transl Oncol. 23: 514-525. PMID: 32656583
- Exosomal CLIC1 released by CLL promotes HUVECs angiogenesis by regulating ITGβ1-MAPK/ERK axis. | Geng, HY., et al. 2021. Kaohsiung J Med Sci. 37: 226-235. PMID: 32841520
- CLIC1 and CLIC4 mediate endothelial S1P receptor signaling to facilitate Rac1 and RhoA activity and function. | Mao, Y., et al. 2021. Sci Signal. 14: PMID: 33879602
- Anti-chloride Intracellular Channel Protein 1 (CLIC1) Antibodies Induce Tumour Necrosis and Angiogenesis Inhibition on In Vivo Experimental Models of Human Renal Cancer. | Radu-Cosnita, AD., et al. 2022. Anticancer Res. 42: 1313-1325. PMID: 35220222
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CLIC1 Antibody (F-9) | sc-374202 | 200 µg/ml | $316.00 | |||
CLIC1 Antibody (F-9): m-IgGκ BP-HRP Bundle | sc-522658 | 200 µg Ab, 40 µg BP | $354.00 | |||
CLIC1 Antibody (F-9) AC | sc-374202 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CLIC1 Antibody (F-9) HRP | sc-374202 HRP | 200 µg/ml | $316.00 | |||
CLIC1 Antibody (F-9) FITC | sc-374202 FITC | 200 µg/ml | $330.00 | |||
CLIC1 Antibody (F-9) PE | sc-374202 PE | 200 µg/ml | $343.00 | |||
CLIC1 Antibody (F-9) Alexa Fluor® 488 | sc-374202 AF488 | 200 µg/ml | $357.00 | |||
CLIC1 Antibody (F-9) Alexa Fluor® 546 | sc-374202 AF546 | 200 µg/ml | $357.00 | |||
CLIC1 Antibody (F-9) Alexa Fluor® 594 | sc-374202 AF594 | 200 µg/ml | $357.00 | |||
CLIC1 Antibody (F-9) Alexa Fluor® 647 | sc-374202 AF647 | 200 µg/ml | $357.00 | |||
CLIC1 Antibody (F-9) Alexa Fluor® 680 | sc-374202 AF680 | 200 µg/ml | $357.00 | |||
CLIC1 Antibody (F-9) Alexa Fluor® 790 | sc-374202 AF790 | 200 µg/ml | $357.00 |