claudin-9 Antibody (E-7): sc-398836
- claudin-9 Antibody (E-7) is a mouse monoclonal IgG1 κ claudin-9 antibody, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 191-217 at the C-terminus of claudin-9 of human origin
- claudin-9 Antibody (E-7) is recommended for detection of claudin-9 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-claudin-9 Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for claudin-9 Antibody (E-7) for WB applications. These reagents are now offered in bundles with claudin-9 Antibody (E-7) (see ordering information below).
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claudin-9 Antibody (E-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects claudin-9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-claudin-9 antibody (E-7) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. claudin-9 plays a crucial role in maintaining tight junction integrity, which is essential for regulating paracellular transport and maintaining cellular polarity. These tight junctions are primarily located in epithelial and endothelial cells, where they form a selective barrier that controls ion and small molecule movement between cells. Proper claudin-9 function is vital for various physiological processes, including barrier function maintenance in tissues such as the cornea and intestines. Notably, claudin-9 shares high homology with claudin-3, which serves as a receptor for clostridium perfringens enterotoxin, highlighting claudin family members′ importance in both health and disease. The human claudin-9 gene is located on chromosome 16p13.3, and expression is tightly regulated, making claudin-9 a significant focus for research in cellular transport mechanisms and potential therapeutic targets.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
claudin-9 Antibody (E-7) References:
- Transmembrane proteins in the tight junction barrier. | Fanning, AS., et al. 1999. J Am Soc Nephrol. 10: 1337-45. PMID: 10361874
- Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein. | Fujita, K., et al. 2000. FEBS Lett. 476: 258-61. PMID: 10913624
- Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut. | Rahner, C., et al. 2001. Gastroenterology. 120: 411-22. PMID: 11159882
- The roles of claudin superfamily proteins in paracellular transport. | Heiskala, M., et al. 2001. Traffic. 2: 93-8. PMID: 11247307
- Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions. | Nishiyama, R., et al. 2001. J Biol Chem. 276: 35571-80. PMID: 11466322
- A claudin-9-based ion permeability barrier is essential for hearing. | Nakano, Y., et al. 2009. PLoS Genet. 5: e1000610. PMID: 19696885
- Functional analysis of claudin-6 and claudin-9 as entry factors for hepatitis C virus infection of human hepatocytes by using monoclonal antibodies. | Fofana, I., et al. 2013. J Virol. 87: 10405-10. PMID: 23864633
- Tongxinluo Reverses the Hypoxia-suppressed Claudin-9 in Cardiac Microvascular Endothelial Cells. | Liu, K., et al. 2016. Chin Med J (Engl). 129: 442-7. PMID: 26879018
- Claudin-9 structures reveal mechanism for toxin-induced gut barrier breakdown. | Vecchio, AJ. and Stroud, RM. 2019. Proc Natl Acad Sci U S A. 116: 17817-17824. PMID: 31434788
- Claudin-9 constitutes tight junctions of folliculo-stellate cells in the anterior pituitary gland. | Higashi, AY., et al. 2021. Sci Rep. 11: 21642. PMID: 34737342
- Claudin‑9 is a novel prognostic biomarker for endometrial cancer. | Endo, Y., et al. 2022. Int J Oncol. 61: PMID: 36129146
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
claudin-9 Antibody (E-7) | sc-398836 | 200 µg/ml | $322.00 | |||
claudin-9 Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-527822 | 200 µg Ab; 10 µg BP | $361.00 | |||
claudin-9 Antibody (E-7): m-IgG1 BP-HRP Bundle | sc-533195 | 200 µg Ab; 20 µg BP | $361.00 | |||
claudin-9 Antibody (E-7) AC | sc-398836 AC | 500 µg/ml, 25% agarose | $424.00 | |||
claudin-9 Antibody (E-7) HRP | sc-398836 HRP | 200 µg/ml | $322.00 | |||
claudin-9 Antibody (E-7) FITC | sc-398836 FITC | 200 µg/ml | $336.00 | |||
claudin-9 Antibody (E-7) PE | sc-398836 PE | 200 µg/ml | $349.00 | |||
claudin-9 Antibody (E-7) Alexa Fluor® 488 | sc-398836 AF488 | 200 µg/ml | $364.00 | |||
claudin-9 Antibody (E-7) Alexa Fluor® 546 | sc-398836 AF546 | 200 µg/ml | $364.00 | |||
claudin-9 Antibody (E-7) Alexa Fluor® 594 | sc-398836 AF594 | 200 µg/ml | $364.00 | |||
claudin-9 Antibody (E-7) Alexa Fluor® 647 | sc-398836 AF647 | 200 µg/ml | $364.00 | |||
claudin-9 Antibody (E-7) Alexa Fluor® 680 | sc-398836 AF680 | 200 µg/ml | $364.00 | |||
claudin-9 Antibody (E-7) Alexa Fluor® 790 | sc-398836 AF790 | 200 µg/ml | $364.00 | |||
claudin-9 (E-7) Neutralizing Peptide | sc-398836 P | 100 µg/0.5 ml | $69.00 |