claudin-19 Antibody (H-4): sc-365968
- claudin-19 Antibody (H-4) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 160-224 mapping at the C-terminus of claudin-19 of human origin
- recommended for detection of claudin-19 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for claudin-19 Antibody (H-4). This work is in progress.
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Claudin-19 Antibody (H-4) is a mouse monoclonal IgG2b antibody that detects claudin-19 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Claudin-19 is a crucial multi-pass membrane protein consisting of 224 amino acids and is part of the claudin family, which plays a vital role in forming and maintaining tight junctions between cells. These tight junctions regulate paracellular transport and maintain epithelial and endothelial barrier integrity. Claudin-19 is expressed in specific tissues and exists in two isoforms due to alternative splicing, which may influence functional properties and protein interactions. Defects in the gene encoding claudin-19 can lead to hypomagnesemia renal with ocular involvement (HOMGO), a serious renal disorder characterized by low magnesium levels, high calcium excretion, and kidney calcification, highlighting claudin-19′s importance in maintaining electrolyte balance and overall renal health. Anti-claudin-19 antibody (H-4) serves as an invaluable tool for researchers studying tight junction dynamics and related pathologies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
claudin-19 Antibody (H-4) | sc-365968 | 200 µg/ml | $322.00 |