claudin-10 Antibody (H-10): sc-373700

claudin-10 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects claudin-10 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-claudin-10 antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. claudin-10 is a critical component of tight junctions, which are essential for maintaining the integrity of epithelial and endothelial barriers. These tight junctions regulate paracellular transport, ensuring that substances pass through the spaces between cells in a controlled manner. claudin-10 consists of four transmembrane domains and two extracellular loops, which facilitate its role in cell adhesion and the formation of tight junction strands. Notably, claudin-10 is involved in the selective permeability of tight junctions, allowing for the passage of certain ions and small molecules while blocking others, which is vital for maintaining homeostasis in various tissues. Expression of claudin-10 is often tissue-specific, highlighting its importance in the physiological functions of different organs. This 228 amino acid multi-pass membrane protein not only contributes to the structural framework of tight junctions but also plays a significant role in signaling pathways that regulate cell behavior and tissue function.

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claudin-10 Antibody (H-10) References:

1. Transmembrane proteins in the tight junction barrier.  |  Fanning, AS., et al. 1999. J Am Soc Nephrol. 10: 1337-45. PMID: 10361874
2. Clostridium perfringens enterotoxin binds to the second extracellular loop of claudin-3, a tight junction integral membrane protein.  |  Fujita, K., et al. 2000. FEBS Lett. 476: 258-61. PMID: 10913624
3. Heterogeneity in expression and subcellular localization of claudins 2, 3, 4, and 5 in the rat liver, pancreas, and gut.  |  Rahner, C., et al. 2001. Gastroenterology. 120: 411-22. PMID: 11159882
4. The roles of claudin superfamily proteins in paracellular transport.  |  Heiskala, M., et al. 2001. Traffic. 2: 93-8. PMID: 11247307
5. Molecular structure of tight junctions and their role in epithelial transport.  |  Anderson, JM. 2001. News Physiol Sci. 16: 126-30. PMID: 11443232
6. Interleukin-2 receptor beta subunit-dependent and -independent regulation of intestinal epithelial tight junctions.  |  Nishiyama, R., et al. 2001. J Biol Chem. 276: 35571-80. PMID: 11466322

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-claudin-10 Antibody (H-10) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-claudin-10 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

claudin-10 Antibody (H-10) Specifications

Alternate Product Name: claudin-10

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 171-228

Epitope Target: claudin-10

Epitope Species: human

Product Reactivity/Detection: claudin-10

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for claudin-10 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin