claudin-1 Antibody (XX7): sc-81796

Claudin-1 Antibody (XX7) is a mouse monoclonal IgG2a kappa light chain antibody raised against recombinant claudin-1 of human origin, detecting claudin-1 from human, mouse, and rat species through applications like western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Claudin-1, also known as CLDN1, is a critical component of the claudin family, involved in forming and maintaining tight junctions in epithelial and endothelial tissues. As a multi-pass membrane protein, claudin-1 is integral to cellular barriers that control paracellular transport, regulating ion permeability and molecule passage between cells. Tight junctions, which include claudin proteins along with occludins and junctional adhesion molecules, are essential for tissue integrity, especially in organs requiring strict barrier functions like the kidney and liver, where claudin-1 is most highly expressed. With four transmembrane domains and two extracellular loops, claudin-1 is structured to facilitate tight junction strand formation, which helps compartmentalize distinct tissue environments. In addition to its role in barrier function, altered claudin-1 expression is linked to various pathologies, with mutations in its gene leading to neonatal ichthyosis-sclerosing cholangitis syndrome, a rare autosomal recessive disorder. Anti-claudin-1 antibody (XX7) is designed to provide precise detection of this key protein across multiple species and applications.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-claudin-1 Antibody (XX7) has 25 citations in a variety of scientific publications.

Primary antibodies like Anti-claudin-1 Antibody (XX7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

claudin-1 Antibody (XX7) Specifications

Alternate Product Name: claudin-1

Product Clone Name: XX7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-212

Epitope Target: claudin-1

Epitope Species: human

Product Reactivity/Detection: claudin-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 25 citations in various scientific publications

Available Conjugates/Forms for claudin-1 Antibody (XX7): N/A

The preferred claudin-1 antibody is claudin-1 Antibody (A-9): sc-166338.