Clathrin Heavy Chain/CLTC Antibody (B-5): sc-271252
- Clathrin Heavy Chain/CLTC Antibody (B-5) is a mouse monoclonal IgG2a κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 1637-1674 at the C-terminus of Clathrin HC of human origin
- recommended for detection of Clathrin HC of mouse, rat, human and origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, porcine and avian
- See Clathrin Heavy Chain/CLTC (TD.1): sc-12734 for Clathrin Heavy Chain/CLTC antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Clathrin Heavy Chain/CLTC Antibody (B-5) for WB applications. This reagent is now offered in a bundle with Clathrin Heavy Chain/CLTC Antibody (B-5) (see ordering information below).
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Clathrin HC Antibody (B-5) is a mouse monoclonal IgG2a light chain antibody that detects Clathrin HC in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Clathrin HC is a crucial component of the clathrin coat, which plays a vital role in endocytosis, a mechanism by which cells internalize molecules and receptors from their surface. Anti-Clathrin HC antibody (B-5) recognizes a protein structure characterized by a triskelion formation, consisting of three heavy chains and three light chains that assemble non-covalently. This unique structure is essential for Clathrin HC function, as Clathrin HC facilitates the invagination of the plasma membrane and the subsequent budding of clathrin-coated vesicles. Clathrin HC contains a terminal globular domain and segments that are critical for binding to light chains, ensuring the stability and functionality of the clathrin coat. Understanding Clathrin HC structure is important because Clathrin HC directly influences the efficiency of receptor-mediated endocytosis, which is vital for nutrient uptake, signal transduction, and the regulation of cell surface receptor levels. Anti-Clathrin HC antibody (B-5) serves as an invaluable tool for researchers studying cellular trafficking and the dynamics of endocytosis in various biological contexts.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Clathrin Heavy Chain/CLTC Antibody (B-5) | sc-271252 | 200 µg/ml | $322.00 | |||
Clathrin Heavy Chain/CLTC Antibody (B-5): m-IgG Fc BP-HRP Bundle | sc-540218 | 200 µg Ab; 10 µg BP | $361.00 | |||
Clathrin Heavy Chain/CLTC (B-5) Neutralizing Peptide | sc-271252 P | 100 µg/0.5 ml | $69.00 |