CKR-4 Antibody (KH-4F5): sc-101375
- CKR-4 Antibody (KH-4F5) is a mouse monoclonal IgG3 κ, cited in 1 publications, provided at 200 µg/ml
- raised against CKR-4 of human origin
- CKR-4 Antibody (KH-4F5) is recommended for detection of CKR-4 of mouse, rat, human origin by WB, IP, IF, FCM and ELISA
- Anti-CKR-4 Antibody (KH-4F5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CKR-4 Antibody (KH-4F5). This work is in progress.
CKR-4 Antibody (KH-4F5) is a mouse monoclonal IgG3 antibody that detects CKR-4 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-CKR-4 antibody (KH-4F5) is available in both non-conjugated and multiple conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and various Alexa Fluor® conjugates. CKR-4, also known as C-C chemokine receptor type 4 or CCR4, is a 360 amino acid multi-pass membrane protein that plays a crucial role in the immune response by acting as a high-affinity receptor for C-C type chemokines. CKR-4 is predominantly expressed in peripheral blood leukocytes and thymus tissue, where CKR-4 is essential for the chemotaxis of T cells and monocytes to sites of inflammation. CKR-4 is involved in the survival of hippocampal neurons, highlighting CKR-4′s importance in neuroprotection and potential implications in neurodegenerative diseases. CKR-4 has been implicated in facilitating viral infections, making CKR-4 a significant target for research in both immunology and virology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CKR-4 Antibody (KH-4F5) References:
- Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2. | Schweickart, VL., et al. 1994. Genomics. 23: 643-50. PMID: 7851893
- HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. | Feng, Y., et al. 1996. Science. 272: 872-7. PMID: 8629022
- Identification of a major co-receptor for primary isolates of HIV-1. | Deng, H., et al. 1996. Nature. 381: 661-6. PMID: 8649511
- HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. | Dragic, T., et al. 1996. Nature. 381: 667-73. PMID: 8649512
- CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. | Alkhatib, G., et al. 1996. Science. 272: 1955-8. PMID: 8658171
- The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. | Choe, H., et al. 1996. Cell. 85: 1135-48. PMID: 8674119
- A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. | Doranz, BJ., et al. 1996. Cell. 85: 1149-58. PMID: 8674120
- Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. | Baba, M., et al. 1997. J Biol Chem. 272: 14893-8. PMID: 9169459
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CKR-4 Antibody (KH-4F5) | sc-101375 | 200 µg/ml | $322.00 | |||
CKR-4 Antibody (KH-4F5) AC | sc-101375 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CKR-4 Antibody (KH-4F5) HRP | sc-101375 HRP | 200 µg/ml | $322.00 | |||
CKR-4 Antibody (KH-4F5) FITC | sc-101375 FITC | 200 µg/ml | $336.00 | |||
CKR-4 Antibody (KH-4F5) PE | sc-101375 PE | 200 µg/ml | $349.00 | |||
CKR-4 Antibody (KH-4F5) Alexa Fluor® 488 | sc-101375 AF488 | 200 µg/ml | $364.00 | |||
CKR-4 Antibody (KH-4F5) Alexa Fluor® 546 | sc-101375 AF546 | 200 µg/ml | $364.00 | |||
CKR-4 Antibody (KH-4F5) Alexa Fluor® 594 | sc-101375 AF594 | 200 µg/ml | $364.00 | |||
CKR-4 Antibody (KH-4F5) Alexa Fluor® 647 | sc-101375 AF647 | 200 µg/ml | $364.00 | |||
CKR-4 Antibody (KH-4F5) Alexa Fluor® 680 | sc-101375 AF680 | 200 µg/ml | $364.00 | |||
CKR-4 Antibody (KH-4F5) Alexa Fluor® 790 | sc-101375 AF790 | 200 µg/ml | $364.00 |