CKR-2B Antibody (H-9): sc-74491

CKR-2B Antibody (H-9) is a mouse monoclonal IgG1 antibody that detects CKR-2B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CKR-2B, a member of the C-C chemokine receptor family, is a 374 amino acid multi-pass membrane protein that plays a crucial role in mediating immune responses by acting as a receptor for various chemokines, including MCP-1 and MCP-3. These interactions are vital as they influence intracellular calcium levels, which in turn affect signal transduction pathways essential for the chemotaxis of immune cells to sites of inflammation. The proper functioning of CKR-2B is not only important for immune surveillance but also has implications in various pathological conditions, including chronic inflammatory diseases and viral infections, where dysregulation of chemokine signaling can exacerbate disease progression. Anti-CKR-2B antibody (H-9) provides a reliable tool for researchers aiming to explore the intricate roles of this receptor in both health and disease, facilitating a deeper understanding of its contributions to immune system dynamics.

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CKR-2B Antibody (H-9) References:

1. C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits.  |  Pimentel-Coelho, PM., et al. 2015. Behav Brain Res. 286: 146-51. PMID: 25746456
2. C-C Chemokine Receptor Type 2 Expression on Monocytes Before Sepsis Onset Is Higher Than That of Postsepsis in Septic Burned Patients: A New Predictor for Sepsis in Burned Injury.  |  Xiu, F., et al. 2016. Ann Surg. 264: 392-8. PMID: 26727083
3. C-C Chemokine Receptor Type 2-Dependent Migration of Myeloid-Derived Suppressor Cells in Protection of Islet Transplants.  |  Qin, J., et al. 2017. Transplantation. 101: 1793-1800. PMID: 27755503
4. C‑C chemokine receptor type 2 promotes epithelial‑to‑mesenchymal transition by upregulating matrix metalloproteinase‑2 in human liver cancer.  |  Li, H., et al. 2018. Oncol Rep. 40: 2734-2741. PMID: 30132565
5. Antifibrogenic effects of C-C chemokine receptor type 2 antagonist in a bleomycin-induced scleroderma model.  |  Ishikawa, M. and Yamamoto, T. 2021. Exp Dermatol. 30: 179-184. PMID: 32096250
6. Diazepam ameliorated myocardial ischemia-reperfusion injury via inhibition of C-C chemokine receptor type 2/tumor necrosis factor-alpha/interleukins and Bcl-2-associated X protein/caspase-3 pathways in experimental rats.  |  Jiang, T., et al. 2021. J Vet Med Sci. 83: 1965-1976. PMID: 34719607
7. Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis.  |  Che, Y., et al. 2022. Bioengineered. 13: 6839-6855. PMID: 35246016
8. MRI Detection of Lymph Node Metastasis through Molecular Targeting of C-C Chemokine Receptor Type 2 and Monocyte Hitchhiking.  |  Trac, N., et al. 2024. ACS Nano. 18: 2091-2104. PMID: 38212302
9. Ketosis prevents abdominal aortic aneurysm rupture through C-C chemokine receptor type 2 downregulation and enhanced extracellular matrix balance.  |  Sastriques-Dunlop, S., et al. 2024. Sci Rep. 14: 1438. PMID: 38228786
10. Inhibition of Macrophage Recruitment to Heart Valves Mediated by the C-C Chemokine Receptor Type 2 Attenuates Valvular Inflammation Induced by Group A Streptococcus in Lewis Rats.  |  Bai, L., et al. 2024. Front Biosci (Landmark Ed). 29: 303. PMID: 39206918

The preferred CKR-2B antibody is CKR-2B Antibody (A-11): sc-74490.