CKR-2B Antibody (A-11): sc-74490

CKR-2B Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects the CKR-2B protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-CKR-2B antibody (A-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CKR-2B, also known as C-C chemokine receptor type 2, is a 374 amino acid multi-pass membrane protein that plays a crucial role in the immune response by mediating the chemotaxis of monocytes and T cells to sites of inflammation. This receptor is part of the C-C chemokine receptor family, which is characterized by a pair of adjacent cysteine residues and is essential for the activation and recruitment of immune cells. CKR-2B specifically binds to chemokines such as monocyte chemoattractant protein-1 (MCP-1) and MCP-3, leading to increased intracellular calcium levels and subsequent signal transduction that influences various cellular responses. Proper functioning of CKR-2B is vital for maintaining immune homeostasis and responding to inflammatory signals; however, dysregulation of this receptor has been implicated in various pathological conditions, including chronic inflammatory diseases and certain viral infections.

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CKR-2B Antibody (A-11) References:

1. C-C chemokine receptor type 2 mediates glomerular injury and interstitial fibrosis in focal segmental glomerulosclerosis.  |  Wilkening, A., et al. 2020. Nephrol Dial Transplant. 35: 227-239. PMID: 30597038
2. Potentials of C-C motif chemokine 2-C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents.  |  Yumimoto, K., et al. 2019. Cancer Sci. 110: 2090-2099. PMID: 31111571
3. C-C chemokine receptor type 2-overexpressing exosomes alleviated experimental post-stroke cognitive impairment by enhancing microglia/macrophage M2 polarization.  |  Yang, HC., et al. 2020. World J Stem Cells. 12: 152-167. PMID: 32184939
4. Recent advances targeting C-C chemokine receptor type 2 for liver diseases in monocyte/macrophage.  |  Li, M., et al. 2020. Liver Int. 40: 2928-2936. PMID: 33025657
5. Cloning of human and mouse EBI1, a lymphoid-specific G-protein-coupled receptor encoded on human chromosome 17q12-q21.2.  |  Schweickart, VL., et al. 1994. Genomics. 23: 643-50. PMID: 7851893
6. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.  |  Feng, Y., et al. 1996. Science. 272: 872-7. PMID: 8629022
7. Identification of a major co-receptor for primary isolates of HIV-1.  |  Deng, H., et al. 1996. Nature. 381: 661-6. PMID: 8649511
8. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.  |  Dragic, T., et al. 1996. Nature. 381: 667-73. PMID: 8649512
9. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.  |  Alkhatib, G., et al. 1996. Science. 272: 1955-8. PMID: 8658171
10. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.  |  Choe, H., et al. 1996. Cell. 85: 1135-48. PMID: 8674119
11. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.  |  Doranz, BJ., et al. 1996. Cell. 85: 1149-58. PMID: 8674120
12. Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC.  |  Baba, M., et al. 1997. J Biol Chem. 272: 14893-8. PMID: 9169459

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CKR-2B Antibody (A-11) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-CKR-2B Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CKR-2B Antibody (A-11) Specifications

Alternate Product Name: CCR2

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-40

Epitope Target: CKR-2B

Epitope Species: human

Product Reactivity/Detection: CKR-2B

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for CKR-2B Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin