CKR-2B Antibody (D-6): sc-515795

CKR-2B Antibody (D-6) is a mouse monoclonal IgG3 antibody that detects CKR-2B in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CKR-2B, a member of the C-C chemokine receptor family, is a 374 amino acid multi-pass membrane protein that plays a crucial role in mediating the immune response by acting as a receptor for various chemokines, including MCP-1 and MCP-3. These interactions influence intracellular calcium levels, which affect signal transduction pathways within the cell, ultimately guiding the migration of immune cells to sites of inflammation. The proper functioning of CKR-2B is essential not only for effective immune responses but also for maintaining homeostasis in the body. CKR-2B has been implicated in facilitating viral infections, highlighting a dual role in both immune regulation and potential pathogenesis. With an ability to influence critical cellular processes, CKR-2B serves as an important target for research into immune responses and related diseases, making anti-CKR-2B antibody (D-6) a valuable tool for scientists studying these complex biological systems.

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CKR-2B Antibody (D-6) References:

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3. C-C chemokine receptor type 2 (CCR2) signaling protects neonatal male mice with hypoxic-ischemic hippocampal damage from developing spatial learning deficits.  |  Pimentel-Coelho, PM., et al. 2015. Behav Brain Res. 286: 146-51. PMID: 25746456
4. T Cells Promote Bronchial Epithelial Cell Secretion of Matrix Metalloproteinase-9 via a C-C Chemokine Receptor Type 2 Pathway: Implications for Chronic Lung Allograft Dysfunction.  |  Pain, M., et al. 2017. Am J Transplant. 17: 1502-1514. PMID: 27982503
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7. Diazepam ameliorated myocardial ischemia-reperfusion injury via inhibition of C-C chemokine receptor type 2/tumor necrosis factor-alpha/interleukins and Bcl-2-associated X protein/caspase-3 pathways in experimental rats.  |  Jiang, T., et al. 2021. J Vet Med Sci. 83: 1965-1976. PMID: 34719607
8. Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis.  |  Che, Y., et al. 2022. Bioengineered. 13: 6839-6855. PMID: 35246016
9. MRI Detection of Lymph Node Metastasis through Molecular Targeting of C-C Chemokine Receptor Type 2 and Monocyte Hitchhiking.  |  Trac, N., et al. 2024. ACS Nano. 18: 2091-2104. PMID: 38212302
10. Inhibition of Macrophage Recruitment to Heart Valves Mediated by the C-C Chemokine Receptor Type 2 Attenuates Valvular Inflammation Induced by Group A Streptococcus in Lewis Rats.  |  Bai, L., et al. 2024. Front Biosci (Landmark Ed). 29: 303. PMID: 39206918

The preferred CKR-2B antibody is CKR-2B Antibody (A-11): sc-74490.