CHRAC17 Antibody (E-11): sc-376242
- CHRAC17 Antibody (E-11) is a mouse monoclonal IgG1 κ CHRAC17 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 67-105 within an internal region of CHRAC17 of human origin
- CHRAC17 Antibody (E-11) is recommended for detection of CHRAC17 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, canine, bovine and porcine
- TransCruz reagent for ChIP application (sc-376242 X, 200 µg/0.1 ml)
- Anti-CHRAC17 Antibody (E-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CHRAC17 Antibody (E-11) for WB applications. These reagents are now offered in bundles with CHRAC17 Antibody (E-11) (see ordering information below).
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CHRAC17 Antibody (E-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects CHRAC17 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CHRAC17 (E-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CHRAC17 plays a crucial role in chromatin remodeling, which is essential for DNA replication and gene expression. CHRAC17 functions as a subunit of the chromatin accessibility complex (CHRAC), which enhances nucleosomal DNA accessibility by utilizing ATP to remodel chromatin structures. This remodeling allows transcriptional regulators to access DNA at the origin of replication, overcoming nucleosome inhibitory effects. CHRAC17, along with CHRAC15, facilitates histone organization into a regularly spaced array, critical for maintaining proper chromatin structure and function. CHRAC′s ability to function during chromatin assembly sets CHRAC apart from other chromatin remodeling factors, making CHRAC17 an important player in gene expression regulation and cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CHRAC17 Antibody (E-11) References:
- Nucleosome movement by CHRAC and ISWI without disruption or trans-displacement of the histone octamer. | Längst, G., et al. 1999. Cell. 97: 843-52. PMID: 10399913
- Multiple ISWI ATPase complexes from xenopus laevis. Functional conservation of an ACF/CHRAC homolog. | Guschin, D., et al. 2000. J Biol Chem. 275: 35248-55. PMID: 10942776
- Critical role for the histone H4 N terminus in nucleosome remodeling by ISWI. | Clapier, CR., et al. 2001. Mol Cell Biol. 21: 875-83. PMID: 11154274
- Chromatin-remodelling factor CHRAC contains the ATPases ISWI and topoisomerase II. | Varga-Weisz, PD., et al. 1997. Nature. 388: 598-602. PMID: 9252192
- In vitro chromatin remodelling by chromatin accessibility complex (CHRAC) at the SV40 origin of DNA replication. | Alexiadis, V., et al. 1998. EMBO J. 17: 3428-38. PMID: 9628878
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CHRAC17 Antibody (E-11) | sc-376242 | 200 µg/ml | $322.00 | |||
CHRAC17 Antibody (E-11): m-IgGκ BP-HRP Bundle | sc-522888 | 200 µg Ab, 40 µg BP | $361.00 | |||
CHRAC17 Antibody (E-11): m-IgG1 BP-HRP Bundle | sc-533532 | 200 µg Ab; 20 µg BP | $361.00 | |||
CHRAC17 Antibody (E-11) X | sc-376242 X | 200 µg/0.1 ml | $322.00 | |||
CHRAC17 Antibody (E-11) AC | sc-376242 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CHRAC17 Antibody (E-11) HRP | sc-376242 HRP | 200 µg/ml | $322.00 | |||
CHRAC17 Antibody (E-11) FITC | sc-376242 FITC | 200 µg/ml | $336.00 | |||
CHRAC17 Antibody (E-11) PE | sc-376242 PE | 200 µg/ml | $349.00 | |||
CHRAC17 Antibody (E-11) Alexa Fluor® 488 | sc-376242 AF488 | 200 µg/ml | $364.00 | |||
CHRAC17 Antibody (E-11) Alexa Fluor® 546 | sc-376242 AF546 | 200 µg/ml | $364.00 | |||
CHRAC17 Antibody (E-11) Alexa Fluor® 594 | sc-376242 AF594 | 200 µg/ml | $364.00 | |||
CHRAC17 Antibody (E-11) Alexa Fluor® 647 | sc-376242 AF647 | 200 µg/ml | $364.00 | |||
CHRAC17 Antibody (E-11) Alexa Fluor® 680 | sc-376242 AF680 | 200 µg/ml | $364.00 | |||
CHRAC17 Antibody (E-11) Alexa Fluor® 790 | sc-376242 AF790 | 200 µg/ml | $364.00 | |||
CHRAC17 (E-11) Neutralizing Peptide | sc-376242 P | 100 µg/0.5 ml | $69.00 |