CHP1 Antibody (B-10): sc-390835

CHP1 Antibody (B-10) is a mouse monoclonal IgG1 antibody that detects CHP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CHP1 is a CHORD domain-containing protein that plays a crucial role in cellular processes, particularly in germline development and embryogenesis. CHP1 (B-10) antibody recognizes unique structural features including tandem CHORD domains at both the N- and C-termini, which are essential for function. These domains are characterized by a 60 amino acid sequence that includes six highly conserved cysteine residues and two histidine residues, forming a distinct zinc-binding motif. This structural integrity is vital as mutations in the CHORD domain of its C. elegans homolog, Chp, have been linked to severe reproductive issues, including semisterility and embryonic lethality. The conservation of CHP1 across various eukaryotic organisms underscores its importance in fundamental biological processes, making anti-CHP1 antibody (B-10) an invaluable tool for researchers studying developmental biology and related fields.

The preferred CHP1 antibody is CHP1 Antibody (B-6): sc-390834.