Chondrolectin Antibody (1A5): sc-517077
- Chondrolectin Antibody (1A5) is a mouse monoclonal IgG2a κ Chondrolectin antibody provided at 100 µg/ml
- raised against amino acids 23-94 representing partial length Chondrolectin of human origin
- recommended for detection of Chondrolectin of mouse, rat and human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Chondrolectin Antibody (1A5). This work is in progress.
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Chondrolectin Antibody (1A5) is a mouse monoclonal IgG2a kappa light chain antibody that detects Chondrolectin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Chondrolectin antibody (1A5) is available as the non-conjugated form. Chondrolectin, also known as transmembrane protein MT75 or CHODL, is an N-glycosylated, single-pass type I membrane protein primarily localized to the endoplasmic reticulum and Golgi apparatus, which is crucial for protein processing and trafficking. This localization facilitates proper folding and modification of proteins before transport to their final destinations, thereby influencing cellular communication and function. Chondrolectin contains one carbohydrate recognition domain and is predominantly expressed in vascular muscle of testis, red pulp of spleen, and smooth muscle of prostate, with additional presence in heart muscle, skeletal muscle, and small intestine. Notably, Chondrolectin shares significant homology with hyaluronan receptor layilin, although Chondrolectin does not appear to interact with hyaluronan. Furthermore, at least two other isoforms of Chondrolectin exist due to alternative splicing, designated CHODLΔE and CHODLfΔE, which are soluble proteins that may play an important role in T cell development.
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Chondrolectin Antibody (1A5) References:
- Molecular cloning and characterization of human chondrolectin, a novel type I transmembrane protein homologous to C-type lectins. | Weng, L., et al. 2002. Genomics. 80: 62-70. PMID: 12079284
- A novel alternative spliced chondrolectin isoform lacking the transmembrane domain is expressed during T cell maturation. | Weng, L., et al. 2003. J Biol Chem. 278: 19164-70. PMID: 12621022
- Isolation and characterization of chondrolectin (Chodl), a novel C-type lectin predominantly expressed in muscle cells. | Weng, L., et al. 2003. Gene. 308: 21-9. PMID: 12711387
- Evidence for linkage on 21q and 7q in a subset of autism characterized by developmental regression. | Molloy, CA., et al. 2005. Mol Psychiatry. 10: 741-6. PMID: 15940295
- Expression and localization of CHODLDeltaE/CHODLfDeltaE, the soluble isoform of chondrolectin. | Claessens, A., et al. 2007. Cell Biol Int. 31: 1323-30. PMID: 17606388
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Chondrolectin Antibody (1A5) | sc-517077 | 100 µg/ml | $322.00 |