chondroitin sulfate Antibody (PG-4): sc-517303

Chondroitin sulfate Antibody (PG-4) is a mouse monoclonal IgM antibody that detects chondroitin sulfate in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-chondroitin sulfate antibody (PG-4) is available as a non-conjugated format. Chondroitin sulfate is a sulfated glycosaminoglycan composed of repeating disaccharide units, which typically link to proteins to form proteoglycans. Chondroitin sulfate predominantly exists in the extracellular matrix, playing a crucial role in maintaining tissue structural integrity and resilience, particularly in cartilage, where chondroitin sulfate contributes significantly to withstanding compressive forces. The unique structure of chondroitin sulfate, with negatively charged sulfate groups, allows interactions with various proteins in the extracellular matrix, facilitating essential cellular processes such as cell signaling, proliferation, and migration. In the nervous system, chondroitin sulfate proteoglycans regulate neuronal growth and development, while modulating response to injury, highlighting importance in both structural and functional contexts. Chondroitin sulfate shows therapeutic potential, commonly used in dietary supplements for alleviating osteoarthritis symptoms.

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chondroitin sulfate Antibody (PG-4) References:

1. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis.  |  McAlindon, TE., et al. 2000. JAMA. 283: 1469-75. PMID: 10732937
2. Biosynthesis of chondroitin/dermatan sulfate.  |  Silbert, JE. and Sugumaran, G. 2002. IUBMB Life. 54: 177-86. PMID: 12512856
3. Chondroitin, a new mucopolysaccharide.  |  DAVIDSON, EA. and MEYER, K. 1954. J Biol Chem. 211: 605-11. PMID: 13221568
4. Chondroitin O-methyl ester: an unusual substrate for chondroitin AC lyase.  |  Avci, FY., et al. 2003. Carbohydr Res. 338: 2101-4. PMID: 14505877
5. Chondroitin sulphate structure affects its immunological activities on murine splenocytes sensitized with ovalbumin.  |  Akiyama, H., et al. 2004. Biochem J. 382: 269-78. PMID: 15147241
6. Chondroitin sulfate in palatal wound healing.  |  Zou, XH., et al. 2004. J Dent Res. 83: 880-5. PMID: 15505240
7. Oxidized chondroitin sulfate-cross-linked gelatin matrixes: a new class of hydrogels.  |  Dawlee, S., et al. 2005. Biomacromolecules. 6: 2040-8. PMID: 16004443
8. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis.  |  Clegg, DO., et al. 2006. N Engl J Med. 354: 795-808. PMID: 16495392
9. Chondroitin product selection for the glucosamine/chondroitin arthritis intervention trial.  |  Barnhill, JG., et al. 2006. J Am Pharm Assoc (2003). 46: 14-24. PMID: 16529337
10. Chondroitin sulfate proteoglycans in the nervous system: inhibitors to repair.  |  Siebert, JR., et al. 2014. Biomed Res Int. 2014: 845323. PMID: 25309928
11. Targeting Chondroitin Sulfate Proteoglycans: An Emerging Therapeutic Strategy to Treat CNS Injury.  |  Mukherjee, N., et al. 2020. ACS Chem Neurosci. 11: 231-232. PMID: 31939650
12. Chondroitin sulfate proteoglycan 4: An attractive target for antibody-based immunotherapy.  |  Kurokawa, T. and Imai, K. 2024. Proc Jpn Acad Ser B Phys Biol Sci. 100: 293-308. PMID: 38735753

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-chondroitin sulfate Antibody (PG-4) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-chondroitin sulfate Antibody (PG-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

chondroitin sulfate Antibody (PG-4) Specifications

Alternate Product Name: chondroitin sulfate

Product Clone Name: PG-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids:

Epitope Target: chondroitin sulfate carbohydrate

Epitope Species: human

Product Reactivity/Detection: a glycosaminoglycan epitope in both dermatan sulfate and chondroitin sulfate proteoglycans of human skin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), FCM

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for chondroitin sulfate Antibody (PG-4): N/A