CHDH Antibody (A-7): sc-514980

CHDH Antibody (A-7) is a mouse monoclonal IgG2b antibody that detects choline dehydrogenase (CHDH) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CHDH is a 594 amino acid protein that plays a crucial role in choline metabolism, converting choline into betaine aldehyde, which is subsequently oxidized to betaine, a vital precursor for methionine synthesis. This enzymatic activity is particularly significant as CHDH levels peak in the kidney and liver, where CHDH localizes to the matrix side of the inner mitochondrial membrane, highlighting CHDH′s importance in cellular energy metabolism and overall cellular function. Estrogen regulation of CHDH suggests potential use as a biomarker for early-stage estrogen receptor-positive breast cancer, especially in predicting anti-estrogen resistance. Furthermore, genetic polymorphisms in the CHDH gene have been associated with varying susceptibility to choline deficiency, underscoring CHDH′s relevance in nutritional biochemistry and health. anti-CHDH antibody (A-7) serves as an essential tool for researchers investigating the role of choline metabolism in health and disease.

The preferred CHDH antibody is CHDH Antibody (C-5): sc-393885.