CHD7 Antibody (F-11): sc-390742

CHD7 Antibody (F-11) is a mouse monoclonal IgM antibody that detects CHD7 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-CHD7 antibody (F-11) is available as the non-conjugated form. Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a 2997 amino acid protein belonging to the SNF2/RAD54 helicase family, characterized by the presence of two chromo domains, one helicase ATP-binding domain, and one helicase C-terminal domain. CHD7 is predominantly expressed in both fetal and adult brain tissues, where CHD7 plays a crucial role as a potential transcription regulator, influencing gene expression and cellular function. Mutations in CHD7 are associated with CHARGE syndrome, a condition that leads to a range of congenital anomalies, including choanal atresia and various malformations affecting the heart, inner ear, and retina. Defects in CHD7 have been linked to an increased risk of idiopathic scoliosis, which is the most prevalent spinal deformity in children. CHD7 exists in two isoforms due to alternative splicing, which may contribute to functional diversity and regulatory mechanisms within the cell.

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CHD7 Antibody (F-11) References:

1. Kallmann syndrome phenotype in a female patient with CHARGE syndrome and CHD7 mutation.  |  Ogata, T., et al. 2006. Endocr J. 53: 741-3. PMID: 16960397
2. Loss of Chd7 function in gene-trapped reporter mice is embryonic lethal and associated with severe defects in multiple developing tissues.  |  Hurd, EA., et al. 2007. Mamm Genome. 18: 94-104. PMID: 17334657
3. An Alu retrotransposition-mediated deletion of CHD7 in a patient with CHARGE syndrome.  |  Udaka, T., et al. 2007. Am J Med Genet A. 143A: 721-6. PMID: 17334995
4. CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis.  |  Gao, X., et al. 2007. Am J Hum Genet. 80: 957-65. PMID: 17436250
5. Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.  |  Kim, HG., et al. 2008. Am J Hum Genet. 83: 511-9. PMID: 18834967
6. Gene symbol: CHD7. Disease: CHARGE syndrome.  |  Ellison, J. 2008. Hum Genet. 124: 323. PMID: 18846688
7. Abnormal basiocciput development in CHARGE syndrome.  |  Fujita, K., et al. 2009. AJNR Am J Neuroradiol. 30: 629-34. PMID: 19112063
8. Clinical and genetic analysis of the CHD7 gene in Korean patients with CHARGE syndrome.  |  Lee, YW., et al. 2009. Clin Genet. 75: 290-3. PMID: 19159393

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CHD7 Antibody (F-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CHD7 Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CHD7 Antibody (F-11) Specifications

Alternate Product Name: CHD7

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 450-473

Epitope Target: CHD7

Epitope Species: human

Product Reactivity/Detection: CHD7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CHD7 Antibody (F-11): P: Blocking Peptide