CGGBP1 Antibody (G-8): sc-376482

CGGBP1 Antibody (G-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects CGGBP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-CGGBP1 antibody (G-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CGGBP1, also known as CGG triplet repeat binding protein 1, plays a crucial role in regulating the fragile X mental retardation 1 (FMR1) gene, which is essential for normal cognitive function. Located predominantly in the nucleus, CGGBP1 binds specifically to the (CGG)n repeat in the promoter region of the FMR1 gene, thereby positively influencing its expression. This interaction is vital because the FMR1 gene is implicated in fragile X syndrome, the most common form of inherited intellectual disability, which arises from the transcriptional silencing of the gene due to extensive methylation of its promoter. In individuals affected by fragile X syndrome, CGGBP1 binding is inhibited, leading to reduced expression of the FMR1 protein and contributing to the cognitive deficits associated with the disorder. CGGBP1 (G-8) antibody enables researchers to gain insights into the molecular mechanisms underlying FMR1 regulation and the pathogenesis of fragile X syndrome.

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CGGBP1 Antibody (G-8) References:

1. Oligomerization properties of fragile-X mental-retardation protein (FMRP) and the fragile-X-related proteins FXR1P and FXR2P.  |  Tamanini, F., et al. 1999. Biochem J. 343 Pt 3: 517-23. PMID: 10527928
2. Isolation of an FMRP-associated messenger ribonucleoprotein particle and identification of nucleolin and the fragile X-related proteins as components of the complex.  |  Ceman, S., et al. 1999. Mol Cell Biol. 19: 7925-32. PMID: 10567518
3. Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein (CGGBP1).  |  Naumann, F., et al. 2004. Genomics. 83: 106-18. PMID: 14667814
4. Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome.  |  Verkerk, AJ., et al. 1991. Cell. 65: 905-14. PMID: 1710175
5. Absence of expression of the FMR-1 gene in fragile X syndrome.  |  Pieretti, M., et al. 1991. Cell. 66: 817-22. PMID: 1878973
6. The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.  |  Zhang, Y., et al. 1995. EMBO J. 14: 5358-66. PMID: 7489725
7. Purification of nuclear proteins from human HeLa cells that bind specifically to the unstable tandem repeat (CGG)n in the human FMR1 gene.  |  Deissler, H., et al. 1996. J Biol Chem. 271: 4327-34. PMID: 8626781
8. The fragile X mental retardation protein is a ribonucleoprotein containing both nuclear localization and nuclear export signals.  |  Eberhart, DE., et al. 1996. Hum Mol Genet. 5: 1083-91. PMID: 8842725
9. Rapid protein sequencing by tandem mass spectrometry and cDNA cloning of p20-CGGBP. A novel protein that binds to the unstable triplet repeat 5'-d(CGG)n-3' in the human FMR1 gene.  |  Deissler, H., et al. 1997. J Biol Chem. 272: 16761-8. PMID: 9201980

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CGGBP1 Antibody (G-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CGGBP1 Antibody (G-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CGGBP1 Antibody (G-8) Specifications

Alternate Product Name: CGGBP1

Product Clone Name: G-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-167

Epitope Target: CGGBP1

Epitope Species: human

Product Reactivity/Detection: CGGBP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CGGBP1 Antibody (G-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent