Centaurin α1 Antibody (F-9): sc-398839

Centaurin α1 Antibody (F-9) is a mouse monoclonal IgM antibody that detects Centaurin α1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Centaurin α1 plays a crucial role in cellular signaling by acting as a high-affinity phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding protein, which is particularly enriched in the brain. Centaurin α1 is essential for regulating the activity of ADP ribosylation factor 6 (ARF6), a key player in membrane trafficking and cytoskeletal organization. By functioning as a GTPase-activating protein, Centaurin α1 effectively switches off ARF6, thereby inhibiting its role in mediating β2-adrenoceptor internalization. This regulatory mechanism is vital for maintaining proper cellular responses and ensuring that signaling pathways are accurately modulated, which is particularly important in neuronal function and development. Anti-Centaurin α1 antibody (F-9) is an invaluable tool for researchers studying the intricate dynamics of cellular signaling and membrane traffic, providing insights into the underlying mechanisms of various physiological and pathological processes.

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Centaurin α1 Antibody (F-9) References:

1. Identification of casein kinase Ialpha interacting protein partners.  |  Dubois, T., et al. 2002. FEBS Lett. 517: 167-71. PMID: 12062430
2. Oligomerization controls in tissue-specific manner ligand binding of native, affinity-purified p42(IP4)/centaurin alpha1 and cytohesins-proteins with high affinity for the messengers D-inositol 1,3,4,5-tetrakisphosphate/phosphatidylinositol 3,4,5-trisphosphate.  |  Stricker, R., et al. 2003. Biochim Biophys Acta. 1651: 102-15. PMID: 14499594
3. Altered expression of protein p42IP4/centaurin-alpha 1 in Alzheimer's disease brains and possible interaction of p42IP4 with nucleolin.  |  Reiser, G. and Bernstein, HG. 2004. Neuroreport. 15: 147-8. PMID: 15106847
4. p42(IP4)/centaurin alpha1, a brain-specific PtdIns(3,4,5)P3/Ins(1,3,4,5)P4-binding protein: membrane trafficking induced by epidermal growth factor is inhibited by stimulation of phospholipase C-coupled thrombin receptor.  |  Sedehizade, F., et al. 2005. Neurochem Res. 30: 1319-30. PMID: 16341594
5. Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity.  |  Stricker, R., et al. 2006. J Neurochem. 98: 343-54. PMID: 16805830
6. Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.  |  Tong, Y., et al. 2010. Proc Natl Acad Sci U S A. 107: 20346-51. PMID: 21057110
7. Retinoic acid-induced upregulation of the metalloendopeptidase nardilysin is accelerated by co-expression of the brain-specific protein p42(IP4) (centaurin α 1; ADAP1) in neuroblastoma cells.  |  Borrmann, C., et al. 2011. Neurochem Int. 59: 936-44. PMID: 21801775
8. Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-α1 (ADAP1).  |  Borrmann, C., et al. 2011. Cell Tissue Res. 346: 89-98. PMID: 21972134
9. Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction.  |  Szatmari, EM., et al. 2013. J Neurosci. 33: 5367-74. PMID: 23516302
10. KIF13A drives AMPA receptor synaptic delivery for long-term potentiation via endosomal remodeling.  |  Gutiérrez, Y., et al. 2021. J Cell Biol. 220: PMID: 33999113