CENPJ Antibody (95.381.1): sc-81432

CENPJ Antibody (95.381.1) is a mouse monoclonal IgG1 antibody that detects CENPJ in human samples through applications such as western blotting (WB) and immunofluorescence (IF). CENPJ, also known as CPAP, is a crucial centromeric protein that significantly influences brain size by regulating the number of neurons during development. CENPJ is characterized by five coiled-coil domains, with the most C-terminal domain featuring a leucine zipper motif, which is essential for protein-protein interactions. Additionally, CENPJ contains multiple potential phosphorylation sites that may play a role in regulation and function. CENPJ is predominantly expressed in the neuroepithelium during prenatal neurogenesis and is localized to the spindle poles of mitotic cells, indicating a vital role in centrosomal mechanisms that control neuron proliferation in the developing mammalian brain. Importantly, mutations in the CENPJ gene have been associated with autosomal recessive primary microcephaly, with a specific 4 base pair deletion identified as a cause of protein truncation, leading to this condition. Anti-CENPJ antibody (95.381.1) is an invaluable tool for researchers studying neurogenesis and related disorders, providing insights into the molecular mechanisms underlying brain development and the impact of genetic mutations.

The preferred CENPJ antibody is CENPJ Antibody (E-12): sc-166113.