CENP-M Antibody (FF6): sc-81830
- CENP-M Antibody (FF6) is a mouse monoclonal IgG1 κ provided at 50 µg/0.5 ml
- raised against recombinant CENP-M of human origin
- recommended for detection of CENP-M of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CENP-M Antibody (FF6). This work is in progress.
CENP-M Antibody (FF6) is a mouse monoclonal IgG1 antibody that detects CENP-M in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). CENP-M, also known as centromere protein M, is a vital 180 amino acid protein that plays a significant role in the assembly of the kinetochore during mitosis, which is essential for accurate chromosome segregation. CENP-M is primarily located in the nucleus of non-confluent cells and shifts to the cytoplasm in dividing or confluent cells, highlighting its dynamic nature and importance in cell division. CENP-M is a key component of the CENPA-NAC complex, which is crucial for the proper functioning of the centromere, and is also involved in the incorporation of newly synthesized CENP-A into centromeres, thereby ensuring the stability and integrity of the genome during cell division. Notably, three isoforms of CENP-M arise from alternative splicing, with isoform 3 being expressed in B-lineage chronic lymphocytic leukemia (B-CLL) cells, suggesting a potential link to cancer development. Anti-CENP-M antibody (FF6) is an invaluable tool for researchers studying the mechanisms of mitosis and the role of centromere proteins in cellular processes and disease states.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CENP-M Antibody (FF6) | sc-81830 | 50 µg/0.5 ml | $316.00 |