CENP-H Antibody (G-9): sc-365222
- CENP-H Antibody (G-9) is a mouse monoclonal IgG2a κ CENP-H antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-247 representing full length CENP-H of human origin
- CENP-H Antibody (G-9) is recommended for detection of CENP-H of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CENP-H Antibody (G-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for CENP-H Antibody (G-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with CENP-H Antibody (G-9) (see ordering information below).
CENP-H Antibody (G-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects CENP-H protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-CENP-H antibody (G-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CENP-H (G-9) monoclonal antibody enables research into CENP-H′s crucial role in kinetochore organization and function, which are essential for accurate chromosome segregation during cell division. CENP-H features a coiled-coil structure and nuclear localization signal, maintaining constitutive localization to kinetochores throughout the cell cycle. This localization ensures proper assembly and stability of the kinetochore complex, necessary for spindle microtubule attachment to chromosomes. Disruption of CENP-H function can lead to chromosome segregation errors, potentially causing aneuploidy, a condition associated with various cancers and genetic disorders. Anti-CENP-H antibody (G-9) supports research into kinetochore function mechanisms and their implications in cell division and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CENP-H Antibody (G-9) References:
- Characterization of a novel kinetochore protein, CENP-H. | Sugata, N., et al. 1999. J Biol Chem. 274: 27343-6. PMID: 10488063
- Centromerization. | Choo, KH. 2000. Trends Cell Biol. 10: 182-8. PMID: 10754560
- Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. | Izuta, H., et al. 2006. Genes Cells. 11: 673-84. PMID: 16716197
- RNAi knockdown of human kinetochore protein CENP-H. | Orthaus, S., et al. 2006. Biochem Biophys Res Commun. 348: 36-46. PMID: 16875666
- Increased expression of CENP-H gene in human oral squamous cell carcinomas harboring high-proliferative activity. | Shigeishi, H., et al. 2006. Oncol Rep. 16: 1071-5. PMID: 17016595
- Centromere protein H is a novel prognostic marker for nasopharyngeal carcinoma progression and overall patient survival. | Liao, WT., et al. 2007. Clin Cancer Res. 13: 508-14. PMID: 17255272
- CENP-B: a major human centromere protein located beneath the kinetochore. | Cooke, CA., et al. 1990. J Cell Biol. 110: 1475-88. PMID: 2335558
- Localization of the centromere protein CENP-B using scleroderma sera and evidence for a role in centromere survival. | Barbosa-Cisneros, O., et al. 1998. Rev Rhum Engl Ed. 65: 15-20. PMID: 9523381
- The vertebrate cell kinetochore and its roles during mitosis. | Rieder, CL. and Salmon, ED. 1998. Trends Cell Biol. 8: 310-8. PMID: 9704407
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CENP-H Antibody (G-9) | sc-365222 | 200 µg/ml | $316.00 | |||
CENP-H Antibody (G-9): m-IgG Fc BP-HRP Bundle | sc-525869 | 200 µg Ab; 10 µg BP | $354.00 | |||
CENP-H Antibody (G-9) AC | sc-365222 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CENP-H Antibody (G-9) HRP | sc-365222 HRP | 200 µg/ml | $316.00 | |||
CENP-H Antibody (G-9) FITC | sc-365222 FITC | 200 µg/ml | $330.00 | |||
CENP-H Antibody (G-9) PE | sc-365222 PE | 200 µg/ml | $343.00 | |||
CENP-H Antibody (G-9) Alexa Fluor® 488 | sc-365222 AF488 | 200 µg/ml | $357.00 | |||
CENP-H Antibody (G-9) Alexa Fluor® 546 | sc-365222 AF546 | 200 µg/ml | $357.00 | |||
CENP-H Antibody (G-9) Alexa Fluor® 594 | sc-365222 AF594 | 200 µg/ml | $357.00 | |||
CENP-H Antibody (G-9) Alexa Fluor® 647 | sc-365222 AF647 | 200 µg/ml | $357.00 | |||
CENP-H Antibody (G-9) Alexa Fluor® 680 | sc-365222 AF680 | 200 µg/ml | $357.00 | |||
CENP-H Antibody (G-9) Alexa Fluor® 790 | sc-365222 AF790 | 200 µg/ml | $357.00 |