CEACAM20 Antibody (HT-12D8): sc-101374

CEACAM20 Antibody (HT-12D8) is a mouse monoclonal IgG1 kappa light chain antibody that detects CEACAM20 protein of human origin by immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-CEACAM20 antibody (HT-12D8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. CEACAM20, or carcinoembryonic antigen-related cell adhesion molecule 20, is a crucial single-pass type I membrane protein composed of 585 amino acids, featuring four immunoglobulin-like C2-type domains. CEACAM20 plays a significant role in cell adhesion processes, which are vital for maintaining tissue architecture and facilitating communication between cells. CEACAM20 functions are essential in various physiological processes, including immune response and tumor progression, as CEACAM20 can influence cell signaling pathways and interactions within the tumor microenvironment. The gene encoding CEACAM20 is located on human chromosome 19, a region rich in immunoglobulin superfamily members, underscoring CEACAM20′s importance in the broader context of immune regulation and cancer biology.

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CEACAM20 Antibody (HT-12D8) References:

1. Synthetic peptides from the N-domains of CEACAMs activate neutrophils.  |  Skubitz, KM., et al. 2001. J Pept Res. 58: 515-26. PMID: 12005421
2. Requirements for CEACAMs and cholesterol during murine coronavirus cell entry.  |  Thorp, EB. and Gallagher, TM. 2004. J Virol. 78: 2682-92. PMID: 14990688
3. Characterization of murine carcinoembryonic antigen gene family members.  |  Rudert, F., et al. 1992. Mamm Genome. 3: 262-73. PMID: 1638085
4. CEACAMs: their role in physiology and pathophysiology.  |  Kuespert, K., et al. 2006. Curr Opin Cell Biol. 18: 565-71. PMID: 16919437
5. Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease.  |  Callaghan, MJ., et al. 2008. Genes Immun. 9: 30-7. PMID: 17960155
6. Carcinoembryonic antigen gene family: molecular biology and clinical perspectives.  |  Thompson, JA., et al. 1991. J Clin Lab Anal. 5: 344-66. PMID: 1941355
7. Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis.  |  Zhang, H., et al. 2013. PLoS One. 8: e53359. PMID: 23358633
8. Regulation by gut commensal bacteria of carcinoembryonic antigen-related cell adhesion molecule expression in the intestinal epithelium.  |  Kitamura, Y., et al. 2015. Genes Cells. 20: 578-89. PMID: 25908210
9. Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.  |  Murata, Y., et al. 2015. Proc Natl Acad Sci U S A. 112: E4264-71. PMID: 26195794
10. Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and Its Functional Role.  |  Daniwijaya, EW., et al. 2013. Kobe J Med Sci. 59: E172-E183. PMID: 28659570
11. The carcinoembryonic antigen gene family: structure, expression and evolution.  |  Thompson, J. and Zimmermann, W. 1988. Tumour Biol. 9: 63-83. PMID: 3041547
12. Characterization of hepatitis B virus DNA integration patterns in intrahepatic cholangiocarcinoma.  |  Li, M., et al. 2021. Hepatol Res. 51: 102-115. PMID: 33037855

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CEACAM20 Antibody (HT-12D8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-CEACAM20 Antibody (HT-12D8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CEACAM20 Antibody (HT-12D8) Specifications

Alternate Product Name: CEACAM20

Product Clone Name: HT-12D8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: CEACAM20

Epitope Species: human

Product Reactivity/Detection: CEACAM20

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, FCM, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for CEACAM20 Antibody (HT-12D8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin