CEACAM19 Antibody (HY-8H10): sc-101373
- CEACAM19 Antibody (HY-8H10) is a mouse monoclonal IgG1 κ CEACAM19 antibody provided at 200 µg/ml
- raised against CEACAM19 of human origin
- CEACAM19 Antibody (HY-8H10) is recommended for detection of CEACAM19 of human origin by FCM and ELISA
- Anti-CEACAM19 Antibody (HY-8H10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for CEACAM19 Antibody (HY-8H10). This reagent is now offered in a bundle with CEACAM19 Antibody (HY-8H10) (see ordering information below).
CEACAM19 Antibody (HY-8H10) is a mouse monoclonal IgG1 kappa light chain antibody that detects CEACAM19 protein of human origin by flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA). Anti-CEACAM19 antibody (HY-8H10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CEACAM19, also known as carcinoembryonic antigen-like 1, is a 300 amino acid protein that belongs to the carcinoembryonic antigen (CEA) family within the immunoglobulin superfamily. This family of proteins plays a crucial role in cell adhesion and signal transduction, making CEACAM19 significant in tumor biology, as CEACAM19 is often expressed in various epithelial tumors, including lung adenocarcinoma and colorectal carcinoma. CEACAM19 is ubiquitously expressed, with highest levels found in the prostate, uterus, mammary gland, adrenal gland, small intestine, kidney, skeletal muscle, and fetal brain, and shows particular abundance in breast and prostate cancer cell lines. CEACAM19 exists in two isoforms due to alternative splicing, which may contribute to functional diversity and regulatory roles in cancer progression. CEACAM19′s ability to mediate cell-cell interactions and influence signaling pathways underscores its potential as a biomarker and therapeutic target in oncology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CEACAM19 Antibody (HY-8H10) References:
- Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. | Scorilas, A., et al. 2003. Gene. 310: 79-89. PMID: 12801635
- Preoperative serum carcinoembryonic antigen level is a prognostic factor in women with early non-small-cell lung cancer. | Hsu, WH., et al. 2007. Ann Thorac Surg. 83: 419-24. PMID: 17257963
- Potent control of tumor growth by CEA/CD3-bispecific single-chain antibody constructs that are not competitively inhibited by soluble CEA. | Lutterbuese, R., et al. 2009. J Immunother. 32: 341-52. PMID: 19342971
- A phase I study of a combination of yttrium-90-labeled anti-carcinoembryonic antigen (CEA) antibody and gemcitabine in patients with CEA-producing advanced malignancies. | Shibata, S., et al. 2009. Clin Cancer Res. 15: 2935-41. PMID: 19351765
- Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis. | Arrieta, O., et al. 2009. BMC Cancer. 9: 119. PMID: 19386089
- Targeted disruption of carcinoembryonic antigen-related cell adhesion molecule 1 promotes diet-induced hepatic steatosis and insulin resistance. | Xu, E., et al. 2009. Endocrinology. 150: 3503-12. PMID: 19406938
- A solid-phase, enzyme-linked immunosorbent assay for a human lung tumor-associated antigen. | Braatz, JA., et al. 1984. J Natl Cancer Inst. 72: 841-6. PMID: 6368940
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CEACAM19 Antibody (HY-8H10) | sc-101373 | 200 µg/ml | $322.00 | |||
CEACAM19 Antibody (HY-8H10): m-IgG1 BP-HRP Bundle | sc-531652 | 200 µg Ab; 20 µg BP | $361.00 | |||
CEACAM19 Antibody (HY-8H10) AC | sc-101373 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CEACAM19 Antibody (HY-8H10) HRP | sc-101373 HRP | 200 µg/ml | $322.00 | |||
CEACAM19 Antibody (HY-8H10) FITC | sc-101373 FITC | 200 µg/ml | $336.00 | |||
CEACAM19 Antibody (HY-8H10) PE | sc-101373 PE | 200 µg/ml | $349.00 | |||
CEACAM19 Antibody (HY-8H10) Alexa Fluor® 488 | sc-101373 AF488 | 200 µg/ml | $364.00 | |||
CEACAM19 Antibody (HY-8H10) Alexa Fluor® 546 | sc-101373 AF546 | 200 µg/ml | $364.00 | |||
CEACAM19 Antibody (HY-8H10) Alexa Fluor® 594 | sc-101373 AF594 | 200 µg/ml | $364.00 | |||
CEACAM19 Antibody (HY-8H10) Alexa Fluor® 647 | sc-101373 AF647 | 200 µg/ml | $364.00 | |||
CEACAM19 Antibody (HY-8H10) Alexa Fluor® 680 | sc-101373 AF680 | 200 µg/ml | $364.00 | |||
CEACAM19 Antibody (HY-8H10) Alexa Fluor® 790 | sc-101373 AF790 | 200 µg/ml | $364.00 |