CDKAL1 Antibody (E-9): sc-393447
- CDKAL1 Antibody (E-9) is a mouse monoclonal IgG1 λ CDKAL1 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-300 mapping at the N-terminus of CDKAL1 of human origin
- CDKAL1 Antibody (E-9) is recommended for detection of CDKAL1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-CDKAL1 Antibody (E-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGλ BP-HRP (mouse IgGλ binding protein-HRP) is the preferred secondary detection reagent for CDKAL1 Antibody (E-9) for WB applications. This reagent is now offered in a bundle with CDKAL1 Antibody (E-9) (see ordering information below). For additional m-IgGλ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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CDKAL1 Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects CDKAL1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). CDKAL1 (E-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CDKAL1 is 579 amino acids long and features a single-pass membrane structure with one TRAM domain, playing a crucial role in glucose-stimulated insulin secretion and maintaining glucose homeostasis in the body. CDKAL1 is predominantly expressed in the pancreas, brain, and skeletal muscle, where CDKAL1 utilizes iron as a cofactor to facilitate function. Defects in CDKAL1 can lead to impaired insulin secretion, contributing to the pathogenesis of type 2 diabetes. Multiple isoforms of CDKAL1, resulting from alternative splicing, highlight the complexity of regulation and function in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CDKAL1 Antibody (E-9) References:
- A variant in CDKAL1 influences insulin response and risk of type 2 diabetes. | Steinthorsdottir, V., et al. 2007. Nat Genet. 39: 770-5. PMID: 17460697
- Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX/IDE are associated with decreased pancreatic beta-cell function. | Pascoe, L., et al. 2007. Diabetes. 56: 3101-4. PMID: 17804762
- Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. | Kirchhoff, K., et al. 2008. Diabetologia. 51: 597-601. PMID: 18264689
- Single-nucleotide polymorphism rs7754840 of CDKAL1 is associated with impaired insulin secretion in nondiabetic offspring of type 2 diabetic subjects and in a large sample of men with normal glucose tolerance. | Stancáková, A., et al. 2008. J Clin Endocrinol Metab. 93: 1924-30. PMID: 18285412
- Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps. | Groenewoud, MJ., et al. 2008. Diabetologia. 51: 1659-63. PMID: 18618095
- Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. | van Hoek, M., et al. 2008. Diabetes. 57: 3122-8. PMID: 18694974
- Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies. | Ruchat, SM., et al. 2009. Acta Diabetol. 46: 217-26. PMID: 19082521
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CDKAL1 Antibody (E-9) | sc-393447 | 200 µg/ml | $322.00 | |||
CDKAL1 Antibody (E-9): m-IgGλ BP-HRP Bundle | sc-523950 | 200 µg Ab, 40 µg BP | $361.00 | |||
CDKAL1 Antibody (E-9) AC | sc-393447 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CDKAL1 Antibody (E-9) HRP | sc-393447 HRP | 200 µg/ml | $322.00 | |||
CDKAL1 Antibody (E-9) FITC | sc-393447 FITC | 200 µg/ml | $336.00 | |||
CDKAL1 Antibody (E-9) PE | sc-393447 PE | 200 µg/ml | $349.00 | |||
CDKAL1 Antibody (E-9) Alexa Fluor® 488 | sc-393447 AF488 | 200 µg/ml | $364.00 | |||
CDKAL1 Antibody (E-9) Alexa Fluor® 546 | sc-393447 AF546 | 200 µg/ml | $364.00 | |||
CDKAL1 Antibody (E-9) Alexa Fluor® 594 | sc-393447 AF594 | 200 µg/ml | $364.00 | |||
CDKAL1 Antibody (E-9) Alexa Fluor® 647 | sc-393447 AF647 | 200 µg/ml | $364.00 | |||
CDKAL1 Antibody (E-9) Alexa Fluor® 680 | sc-393447 AF680 | 200 µg/ml | $364.00 | |||
CDKAL1 Antibody (E-9) Alexa Fluor® 790 | sc-393447 AF790 | 200 µg/ml | $364.00 |