Cdk7 Antibody (D-5): sc-271794
- Cdk7 Antibody (D-5) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 317-346 at the C-terminus of Cdk7 of human origin
- recommended for detection of Cdk7 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine, bovine and porcine
- See Cdk7 (C-4): sc-7344 for Cdk7 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP is the preferred secondary detection reagent for Cdk7 Antibody (D-5) for WB applications. This reagent is now offered in a bundle with Cdk7 Antibody (D-5) (see ordering information below).
Cdk7 Antibody (D-5) is a mouse monoclonal IgG2b antibody that detects Cdk7 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Cdk7 plays a pivotal role in the regulation of the cell cycle by functioning as a cyclin-dependent kinase-activating kinase (CAK), which is essential for the activation of other cyclin-dependent kinases, including Cdk2 and Cdc2. Cdk7 phosphorylates these kinases at specific threonine residues, which is crucial for their full activation and subsequent progression through the cell cycle. Notably, Cdk7 is part of a larger complex that includes cyclin H, which is necessary for its activity, and the catalytic subunit Cdk7 is homologous to the MO15 protein kinase found in lower organisms. The precise regulation of Cdk7 and its interactions with cyclins and other proteins are vital for maintaining proper cell cycle control, and dysregulation of this pathway can lead to various diseases, including cancer. anti-Cdk7 antibody (D-5) is an invaluable tool for researchers studying cell cycle dynamics and the molecular mechanisms underlying cell proliferation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdk7 Antibody (D-5) | sc-271794 | 200 µg/ml | $322.00 | |||
Cdk7 Antibody (D-5): m-IgG2b BP-HRP Bundle | sc-548543 | 200 µg Ab; 10 µg BP | $361.00 | |||
Cdk7 (D-5) Neutralizing Peptide | sc-271794 P | 100 µg/0.5 ml | $69.00 |