Cdk7 Antibody (C-4): sc-7344

Cdk7 Antibody (C-4) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cdk7 protein of mouse, rat, and human origin through various applications including western blotting, immunoprecipitation, immunofluorescence, immunohistochemistry, and enzyme-linked immunosorbent assay. Cdk7 (C-4) antibody is available in both non-conjugated and multiple conjugated forms, such as agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and various Alexa Fluor® conjugates. Cdk7 plays a crucial role in cell cycle regulation as part of the cyclin-dependent kinase-activating kinase (CAK) complex, which is essential for the activation of other cyclin-dependent kinases, including Cdk2 and Cdc2. By phosphorylating these kinases at specific threonine residues, Cdk7 ensures that the cell cycle progresses smoothly, allowing for proper cellular division and function. Cdk7 serves as a regulatory hub that integrates various signaling pathways, thereby influencing cellular responses to external stimuli. Given the pivotal role in cell cycle control, Cdk7 is a significant target for research in cancer biology, where dysregulation of cell cycle progression is a hallmark of tumorigenesis.

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Cdk7 Antibody (C-4) References:

1. A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1.  |  Pinhero, R., et al. 2004. Biol Proced Online. 6: 163-172. PMID: 15328539
2. The crystal structure of human CDK7 and its protein recognition properties.  |  Lolli, G., et al. 2004. Structure. 12: 2067-79. PMID: 15530371
3. Gambogic acid-induced G2/M phase cell-cycle arrest via disturbing CDK7-mediated phosphorylation of CDC2/p34 in human gastric carcinoma BGC-823 cells.  |  Yu, J., et al. 2007. Carcinogenesis. 28: 632-8. PMID: 17012222
4. Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.  |  Larochelle, S., et al. 2007. Mol Cell. 25: 839-50. PMID: 17386261
5. Phosphorylation of steroidogenic factor 1 is mediated by cyclin-dependent kinase 7.  |  Lewis, AE., et al. 2008. Mol Endocrinol. 22: 91-104. PMID: 17901130
6. CDK7 inhibitors as anticancer drugs.  |  Sava, GP., et al. 2020. Cancer Metastasis Rev. 39: 805-823. PMID: 32385714
7. CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma.  |  Yao, Y., et al. 2023. Blood. 141: 2841-2852. PMID: 36877894
8. CDK7-YAP-LDHD axis promotes D-lactate elimination and ferroptosis defense to support cancer stem cell-like properties.  |  Lv, M., et al. 2023. Signal Transduct Target Ther. 8: 302. PMID: 37582812
9. Activation of cyclin-dependent kinase 4 (cdk4) by mouse MO15-associated kinase.  |  Matsuoka, M., et al. 1994. Mol Cell Biol. 14: 7265-75. PMID: 7935441
10. Cyclins and cancer. II: Cyclin D and CDK inhibitors come of age.  |  Hunter, T. and Pines, J. 1994. Cell. 79: 573-82. PMID: 7954824
11. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase.  |  Kato, JY., et al. 1994. Mol Cell Biol. 14: 2713-21. PMID: 8139570
12. Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.  |  Levedakou, EN., et al. 1994. Oncogene. 9: 1977-88. PMID: 8208544

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cdk7 Antibody (C-4) has 70 citations in a variety of scientific publications.

Primary antibodies like Anti-Cdk7 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cdk7 Antibody (C-4) Specifications

Alternate Product Name: Cdk7

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-346

Epitope Target: Cdk7

Epitope Species: human

Product Reactivity/Detection: Cdk7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 70 citations in various scientific publications

Available Conjugates/Forms for Cdk7 Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, TRITC: Rhodamine