Cdk3 Antibody (4B6): sc-81836
- Cdk3 Antibody (4B6) is a mouse monoclonal IgG1 κ Cdk3 antibody provided at 100 µg/ml
- raised against a partial recombinant protein corresponding to the C-terminus of Cdk3 of human origin
- recommended for detection of Cdk3 of human origin by WB, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cdk3 Antibody (4B6). This work is in progress.
Cdk3 Antibody (4B6) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Cdk3 protein of human origin by western blotting (WB), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-Cdk3 antibody (4B6) is available as the non-conjugated format. Cdk3 plays a crucial role in regulating cell cycle, particularly in transitioning from G1 phase to S phase, where DNA replication occurs. This transition is vital for proper cell division and growth, and dysregulation of Cdk3 can lead to uncontrolled cell proliferation, a hallmark of cancer. Cdk3 functions with cyclins to phosphorylate target substrates, facilitating cell cycle progression. Cdk3 belongs to a larger family of cyclin-dependent kinases, including Cdk2, Cdk4, and Cdk6, which are essential for various phases of cell cycle regulation. Cdk3′s role in cell cycle control has gained attention in cancer research, as changes in expression or activity may contribute to tumorigenesis, making Cdk3 a potential target for therapeutic intervention.
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Cdk3 Antibody (4B6) References:
- PCTAIRE-1 and PCTAIRE-3, two members of a novel cdc2/CDC28-related protein kinase gene family. | Okuda, T., et al. 1992. Oncogene. 7: 2249-58. PMID: 1437147
- Cyclin C/cdk3 promotes Rb-dependent G0 exit. | Ren, S. and Rollins, BJ. 2004. Cell. 117: 239-51. PMID: 15084261
- Cdk3-promoted epithelial-mesenchymal transition through activating AP-1 is involved in colorectal cancer metastasis. | Lu, J., et al. 2016. Oncotarget. 7: 7012-28. PMID: 26755651
- A PTP1B-Cdk3 Signaling Axis Promotes Cell Cycle Progression of Human Glioblastoma Cells through an Rb-E2F Dependent Pathway. | Villamar-Cruz, O., et al. 2023. Mol Cell Biol. 43: 631-649. PMID: 38014992
- The cell cycle kinases. | Pines, J. 1994. Semin Cancer Biol. 5: 305-13. PMID: 7803767
- Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, p27Kip1, to regions involved in human cancer. | Bullrich, F., et al. 1995. Cancer Res. 55: 1199-205. PMID: 7882308
- Cyclins, cyclin-dependent kinases and cdk inhibitors: implications in cell cycle control and cancer. | MacLachlan, TK., et al. 1995. Crit Rev Eukaryot Gene Expr. 5: 127-56. PMID: 8845581
- Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit. | Hofmann, F. and Livingston, DM. 1996. Genes Dev. 10: 851-61. PMID: 8846921
- Role of the cyclin-dependent kinase 4 and 6 inhibitor gene family p15, p16, p18 and p19 in leukemia and lymphoma. | Siebert, R., et al. 1996. Leuk Lymphoma. 23: 505-20. PMID: 9031081
- Current concepts in neuro-oncology: the cell cycle--a review. | Dirks, PB. and Rutka, JT. 1997. Neurosurgery. 40: 1000-13; discussion 1013-5. PMID: 9149259
- Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation. | Braun, K., et al. 1998. Oncogene. 17: 2259-69. PMID: 9811456
- Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. | Zariwala, M., et al. 1998. Oncogene. 17: 2787-98. PMID: 9840943
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdk3 Antibody (4B6) | sc-81836 | 100 µg/ml | $339.00 |