Cdk11 Antibody (8B6): sc-517026

Cdk11 Antibody (8B6) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cdk11 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Cdk11 antibody (8B6) is available as the non-conjugated format. Cdk11, also known as cyclin-dependent kinase 11 or CDC2L6, plays a crucial role in regulating the cell cycle by phosphorylating key substrates essential for cell cycle progression. Cdk11 is primarily located in the nucleus, where Cdk11 is involved in the regulation of transcription and RNA processing, highlighting its importance in both cell division and gene expression. Cdk11 interacts with various transcription factors and components of the mediator complex in the nucleus, thereby influencing the transcriptional activation of target genes. Cdk11 undergoes alternative splicing, resulting in multiple isoforms that may have distinct functions or regulatory mechanisms. The gene encoding Cdk11 is located on human chromosome 6, which encompasses a large portion of the human genome, indicating the potential complexity and regulatory networks associated with Cdk11.

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Cdk11 Antibody (8B6) References:

1. A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.  |  Sato, S., et al. 2004. Mol Cell. 14: 685-91. PMID: 15175163
2. CDK11(p58) protein kinase activity is associated with Bcl-2 down-regulation in pro-apoptosis pathway.  |  Yun, X., et al. 2007. Mol Cell Biochem. 304: 213-8. PMID: 17516030
3. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection.  |  Loyer, P., et al. 2008. J Biol Chem. 283: 7721-32. PMID: 18216018
4. Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate.  |  Yokoyama, H., et al. 2008. J Cell Biol. 180: 867-75. PMID: 18316407
5. Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation.  |  Tsutsui, T., et al. 2008. Genes Cells. 13: 817-26. PMID: 18651850
6. A human snoRNA with microRNA-like functions.  |  Ender, C., et al. 2008. Mol Cell. 32: 519-28. PMID: 19026782
7. Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.  |  Shi, J., et al. 2009. FEBS Lett. 583: 971-7. PMID: 19245811

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Cdk11 Antibody (8B6) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Cdk11 Antibody (8B6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Cdk11 Antibody (8B6) Specifications

Alternate Product Name: Cdk11

Product Clone Name: 8B6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 367-467

Epitope Target: Cdk11

Epitope Species: human

Product Reactivity/Detection: Cdk11

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Cdk11 Antibody (8B6): N/A