Cdc2 p34 Antibody (164E2Y): sc-517612
- Cdc2 p34 Antibody (164E2Y) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against amino acids 1-297 of Cdc2 p34 of human origin
- recommended for detection of Cdc2 p34 of human origin by WB
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cdc2 p34 Antibody (164E2Y). This work is in progress.
Cdc2 p34 Antibody (164E2Y) is a mouse monoclonal IgG1 antibody that detects Cdc2 in human samples through western blotting (WB). Cdc2, an evolutionarily conserved serine/threonine-specific protein kinase, plays a pivotal role in regulating the cell cycle, particularly in the transition from the G2 phase to the M phase. This transition is crucial for proper cell division and overall cellular function, as anti-Cdc2 antibody (164E2Y) ensures that cells only enter mitosis when fully prepared, thereby preventing errors that could lead to genomic instability or cancer. The activity of Cdc2 is tightly regulated by association with B-type cyclins and by reversible phosphorylation at key regulatory sites, including threonine 14, tyrosine 15, and threonine 161. The binding of Cyclin B to Cdc2 facilitates the phosphorylation of these sites, with the phosphorylation of Thr 14 and Tyr 15 serving as a negative regulatory mechanism, while the phosphorylation of Thr 161 acts as a positive regulator. The dynamic interplay of these phosphorylation events is essential for proper progression through the cell cycle, highlighting the importance of Cdc2 in maintaining cellular integrity and function. Cdc2 (164E2Y) monoclonal antibody serves as an invaluable tool for researchers studying cell cycle regulation and its implications in various diseases.
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cdc2 p34 Antibody (164E2Y) | sc-517612 | 100 µg/ml | $316.00 |