CD92 Antibody (1C4): sc-517098

CD92 Antibody (1C4) is a mouse monoclonal IgG2a kappa light chain antibody that detects CD92 protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CD92 antibody (1C4) is available as the non-conjugated format. CD92, also known as SLC44A1 (solute carrier family 44, member 1), CDw92, or CTL1 (choline transporter-like protein 1), is a 657 amino acid multi-pass membrane protein that plays a crucial role in the transport of choline across cell membranes, which is essential for the synthesis of phospholipids and myelin. This function is particularly important in the context of the nervous system, where myelin is vital for the proper conduction of electrical impulses along neurons. CD92 expression in hematopoietic cells suggests involvement in various physiological processes, including membrane synthesis and cellular signaling. Human CD92 shares 96% sequence homology with mouse CD92, indicating a conserved role across species. Additionally, three isoforms of CD92 arise from alternative splicing, which may contribute to functional diversity. CD92 gene is located on human chromosome 9, a region significant not only for numerous genes but also for association with hereditary hemorrhagic telangiectasia and familial dysautonomia, both linked to vascular and autonomic dysfunctions. CD92 presence in various tissues highlights potential as a biomarker for research into neurological and hematological disorders.

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CD92 Antibody (1C4) References:

1. An electric lobe suppressor for a yeast choline transport mutation belongs to a new family of transporter-like proteins.  |  O'Regan, S., et al. 2000. Proc Natl Acad Sci U S A. 97: 1835-40. PMID: 10677542
2. Characterization of CDw92 as a member of the choline transporter-like protein family regulated specifically on dendritic cells.  |  Wille, S., et al. 2001. J Immunol. 167: 5795-804. PMID: 11698453
3. Differential expression and regulation of the high-affinity choline transporter CHT1 and choline acetyltransferase in neurons of superior cervical ganglia.  |  Lecomte, MJ., et al. 2005. Mol Cell Neurosci. 28: 303-13. PMID: 15691711
4. Molecular characterization of the family of choline transporter-like proteins and their splice variants.  |  Traiffort, E., et al. 2005. J Neurochem. 92: 1116-25. PMID: 15715662
5. Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 monocyte-derived macrophages.  |  Fullerton, MD., et al. 2006. Am J Physiol Cell Physiol. 290: C1230-8. PMID: 16319125
6. Genomic organization, promoter activity, and expression of the human choline transporter-like protein 1.  |  Yuan, Z., et al. 2006. Physiol Genomics. 26: 76-90. PMID: 16609143

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD92 Antibody (1C4) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-CD92 Antibody (1C4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD92 Antibody (1C4) Specifications

Alternate Product Name: CD92

Product Clone Name: 1C4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 74-183

Epitope Target: CD92

Epitope Species: human

Product Reactivity/Detection: CD92

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for CD92 Antibody (1C4): N/A