CD8-α Antibody (53-6.7): sc-18913
- CD8-α Antibody (53-6.7) is a rat monoclonal IgG2a, cited in 21 publications, provided at 200 µg/ml
- raised against spleen cells of mouse origin
- CD8-alpha Antibody (53-6.7) is recommended for detection of CD8-α chain of mouse origin by IP, IF, IHC(P) and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to either APC or APC-Cy7 for IF, IHC(P) and FCM
- available azide-free for in vitro and in vivo depletion, inhibition of T-cell responses to IL-2, and blocking of cytotoxicity (sc-18913 L, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for CD8-α Antibody (53-6.7). This work is in progress.
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CD8-α Antibody (53-6.7) is a rat monoclonal IgG2a antibody that targets the CD8-α chain in mice and is recommended for use in immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). CD8-α monoclonal antibody (53-6.7) is raised against spleen cells from mice and recognizes CD8-α, also known as T8 or Leu-2, a critical component of the T cell receptor (TCR) complex on cytotoxic T lymphocytes. CD8-α acts as a co-receptor, binding to major histocompatibility complex (MHC) class I molecules on antigen-presenting cells (APCs), enhancing antigen recognition and TCR signaling, which is essential for the immune system′s ability to target and eliminate infected or malignant cells. The study of CD8-α is pivotal for understanding adaptive immune responses, autoimmune conditions, and the development of novel therapeutic strategies, making CD8-α antibody (53-6.7) an invaluable tool for researchers aiming to investigate T cell-mediated immunity and its implications in various disease models. Available in both conjugated and unconjugated forms, CD8-α monoclonal antibody (53-6.7) is a versatile tool for various experimental applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD8-α Antibody (53-6.7) References:
- The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. | Janeway, CA. 1992. Annu Rev Immunol. 10: 645-74. PMID: 1534242
- Thymic differentiation of TCR alpha beta(+) CD8 alpha alpha(+) IELs. | Lambolez, F., et al. 2007. Immunol Rev. 215: 178-88. PMID: 17291288
- The immunobiology of T cells with invariant gamma delta antigen receptors. | Allison, JP. and Havran, WL. 1991. Annu Rev Immunol. 9: 679-705. PMID: 1832874
- CD4 and CD8 act as co-receptors during thymic selection of the T cell repertoire. | Zúñiga-Pflücker, JC., et al. 1991. Semin Immunol. 3: 167-75. PMID: 1909594
- CD4 and CD8 recognition of class II and class I molecules of the major histocompatibility complex. | Fleury, SG., et al. 1991. Semin Immunol. 3: 177-85. PMID: 1909595
- The CD8+ dendritic cell subset. | Shortman, K. and Heath, WR. 2010. Immunol Rev. 234: 18-31. PMID: 20193009
- Structure and expression of the gene encoding CD8 alpha chain (Leu-2/T8). | Nakayama, K., et al. 1989. Immunogenetics. 30: 393-7. PMID: 2509342
- HIV-specific CD8+ T-cell immune responses and viral replication. | Buseyne, F. and Rivière, Y. 1993. AIDS. 7 Suppl 2: S81-5. PMID: 7909230
- T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen. | Ehrich, EW., et al. 1993. J Exp Med. 178: 713-22. PMID: 8393480
- Distinct roles for CD4 and CD8 as co-receptors in antigen receptor signalling. | Julius, M., et al. 1993. Immunol Today. 14: 177-83. PMID: 8499078
- CD8+ T-cell clones in old mice. | Ku, CC., et al. 1997. Immunol Rev. 160: 139-44. PMID: 9476672
- A novel leukocyte adhesion deficiency caused by expressed but nonfunctional beta2 integrins Mac-1 and LFA-1. | Hogg, N., et al. 1999. J Clin Invest. 103: 97-106. PMID: 9884339
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD8-α Antibody (53-6.7) | sc-18913 | 200 µg/ml | $316.00 | |||
CD8-α Antibody (53-6.7) L | sc-18913 L | 200 µg/0.1 ml | $316.00 | |||
CD8-α Antibody (53-6.7) FITC | sc-18913 FITC | 200 µg/ml | $330.00 | |||
CD8-α Antibody (53-6.7) PE | sc-18913 PE | 200 µg/ml | $343.00 | |||
CD8-α Antibody (53-6.7) Alexa Fluor® 488 | sc-18913 AF488 | 200 µg/ml | $357.00 | |||
CD8-α Antibody (53-6.7) Alexa Fluor® 546 | sc-18913 AF546 | 200 µg/ml | $357.00 | |||
CD8-α Antibody (53-6.7) Alexa Fluor® 594 | sc-18913 AF594 | 200 µg/ml | $357.00 | |||
CD8-α Antibody (53-6.7) Alexa Fluor® 647 | sc-18913 AF647 | 200 µg/ml | $357.00 | |||
CD8-α Antibody (53-6.7) Alexa Fluor® 680 | sc-18913 AF680 | 200 µg/ml | $357.00 | |||
CD8-α Antibody (53-6.7) Alexa Fluor® 790 | sc-18913 AF790 | 200 µg/ml | $357.00 | |||
CD8-α Antibody (53-6.7) APC | sc-18913 APC | 100 tests in 2 ml | $351.00 | |||
CD8-α Antibody (53-6.7) APC-Cy7) APCC7 | sc-18913 APCC7 | 100 tests in 2 ml | $369.00 |