CD79A Antibody (HM57): sc-53208
- CD79A Antibody (HM57) is a mouse monoclonal IgG1 κ, cited in 12 publications, provided at 200 µg/ml
- raised against synthetic peptide corresponding to amino acids 202-216 of the human mb-1 cDNA sequence
- CD79A Antibody (HM57) is recommended for detection of CD79A of mouse, rat, human and origin by WB, IP, IF and IHC(P); also reactive with additional species, including and Porcine, Bovine, Canine, Chicken, Equine, Guinea Pig, Monkey, Rabbit
- Anti-CD79A Antibody (HM57) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for CD79A Antibody (HM57) for WB and IHC(P) applications. These reagents are now offered in bundles with CD79A Antibody (HM57) (see ordering information below).
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CD79A Antibody (HM57) is a mouse monoclonal IgG1 kappa light chain antibody that detects CD79A protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-CD79A antibody (HM57) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CD79A, also known as MB-1, is a crucial component of the B cell antigen receptor complex, which plays a vital role in B cell activation and immune response. CD79A protein is located on the surface of B cells, where CD79A forms a heterodimer with CD79B, facilitating association with membrane immunoglobulins such as IgM and IgD. This interaction is essential for effective surface expression of these immunoglobulins, enabling B cells to present antigens and initiate immune responses. Additionally, cytoplasmic tails of CD79A and CD79B contain immuno-receptor tyrosine-based activation motifs (ITAMs) that are critical for triggering downstream signaling pathways upon antigen binding, ultimately leading to B cell activation and proliferation. CD79A′s ability to mediate these processes underscores its importance in the adaptive immune system, making CD79A (HM57) monoclonal antibody a valuable tool for researchers studying B cell biology and related immunological functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD79A Antibody (HM57) References:
- Flow cytometric detection of CD79a expression in T-cell acute lymphoblastic leukemias. | Lai, R., et al. 2000. Am J Clin Pathol. 113: 823-30. PMID: 10874883
- Immunohistochemical detection of CD79a expression in precursor T cell lymphoblastic lymphoma/leukaemias. | Hashimoto, M., et al. 2002. J Pathol. 197: 341-7. PMID: 12115880
- CD79a is heterogeneously expressed in neoplastic and normal myeloid precursors and megakaryocytes in an antibody clone-dependent manner. | Bhargava, P., et al. 2007. Am J Clin Pathol. 128: 306-13. PMID: 17638667
- Presence of CD3+ and CD79a+ Lymphocytes in the Pituitary Gland of Dogs at Post-mortem Examination. | Blomqvist, MA., et al. 2020. J Comp Pathol. 176: 116-121. PMID: 32359623
- Compromised antigen binding and signaling interfere with bispecific CD19 and CD79a chimeric antigen receptor function. | Leung, I., et al. 2023. Blood Adv. 7: 2718-2730. PMID: 36469024
- Enrichment of T-cell proliferation and memory gene signatures of CD79A/CD40 costimulatory domain potentiates CD19CAR-T cell functions. | Ung, S., et al. 2022. Front Immunol. 13: 1064339. PMID: 36505428
- Prediction of prognosis and immunotherapy response in lung adenocarcinoma based on CD79A, DKK1 and VEGFC. | Zhang, Q., et al. 2023. Heliyon. 9: e18503. PMID: 37534013
- Expanding the Clinical Phenotype with CD79A Mutation and Refractory Helicobacter Bilis Infection. | Sil, A., et al. 2024. J Clin Immunol. 44: 187. PMID: 39215847
- Alternative splicing of CD79a (Ig-alpha/mb-1) and CD79b (Ig-beta/B29) RNA transcripts in human B cells. | Hashimoto, S., et al. 1995. Mol Immunol. 32: 651-9. PMID: 7643857
- Co-expression of CD79a (JCB117) and CD3 by lymphoblastic lymphoma. | Pilozzi, E., et al. 1998. J Pathol. 186: 140-3. PMID: 9924428
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD79A Antibody (HM57) | sc-53208 | 200 µg/ml | $322.00 | |||
CD79A Antibody (HM57): m-IgG Fc BP-HRP Bundle | sc-526779 | 200 µg Ab; 10 µg BP | $361.00 | |||
CD79A Antibody (HM57): m-IgG1 BP-HRP Bundle | sc-532152 | 200 µg Ab; 20 µg BP | $361.00 | |||
CD79A Antibody (HM57) AC | sc-53208 AC | 500 µg/ml, 25% agarose | $424.00 | |||
CD79A Antibody (HM57) HRP | sc-53208 HRP | 200 µg/ml | $322.00 | |||
CD79A Antibody (HM57) FITC | sc-53208 FITC | 200 µg/ml | $336.00 | |||
CD79A Antibody (HM57) PE | sc-53208 PE | 200 µg/ml | $349.00 | |||
CD79A Antibody (HM57) Alexa Fluor® 488 | sc-53208 AF488 | 200 µg/ml | $364.00 | |||
CD79A Antibody (HM57) Alexa Fluor® 546 | sc-53208 AF546 | 200 µg/ml | $364.00 | |||
CD79A Antibody (HM57) Alexa Fluor® 594 | sc-53208 AF594 | 200 µg/ml | $364.00 | |||
CD79A Antibody (HM57) Alexa Fluor® 647 | sc-53208 AF647 | 200 µg/ml | $364.00 | |||
CD79A Antibody (HM57) Alexa Fluor® 680 | sc-53208 AF680 | 200 µg/ml | $364.00 | |||
CD79A Antibody (HM57) Alexa Fluor® 790 | sc-53208 AF790 | 200 µg/ml | $364.00 |