CD74 Antibody (In-1): sc-19627

CD74 Antibody (In-1) is a rat monoclonal IgG2b antibody that detects CD74 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). CD74, also known as the invariant chain, plays a crucial role in the immune system by regulating the loading of peptides onto major histocompatibility complex class II (MHC II) molecules. This process is vital for the proper presentation of antigens to T lymphocytes, which is essential for initiating adaptive immune responses. The interaction between CD74 and MHC II occurs during the transport of MHC II to the endosomal compartment, where peptide binding takes place. CD74 is expressed on various immune cells, including B lymphocytes, where CD74 is found regardless of the histocompatibility leukocyte antigen (HLA) phenotype, while a subset of peripheral T lymphocytes that lack MHC II do not express CD74. The presence of CD74 on immune cells highlights CD74′s importance in maintaining immune homeostasis and facilitating effective immune responses, making anti-CD74 antibody (In-1) a valuable tool for researchers studying immune function and related disorders.

The preferred CD74 antibody is CD74 Antibody (LN-2): sc-6262.