CD71/TFRC/Transferrin Receptor Antibody (2B6): sc-51829

CD71 Antibody (2B6) is a mouse monoclonal IgG2a antibody that detects CD71 in human samples through western blotting (WB) and immunoprecipitation (IP). CD71, also known as transferrin receptor (TFR), is a type II membrane glycoprotein that plays a crucial role in iron homeostasis by facilitating cellular uptake of iron through receptor-mediated endocytosis. CD71 exists as a disulfide-linked homodimer, binding to two molecules of transferrin, which is essential for transporting iron in the bloodstream. CD71 is predominantly expressed on proliferating cells, reticulocytes, and erythroid precursors, making CD71 a vital marker for cell proliferation and differentiation. While CD71 is not present on resting leukocytes, CD71 expression significantly increases upon activation of lymphocytes, monocytes, and macrophages, indicating CD71′s importance in immune responses. CD71 is found on most dividing cells and brain endothelium, highlighting CD71′s diverse roles in various tissues. A second transferrin receptor, TFR2, highly expressed in the liver and mediating transferrin-bound iron uptake, further underscores the complexity of iron regulation in the body. Mutations in the TFR2 gene can lead to hereditary hemochromatosis type III, an iron overload disorder particularly affecting Caucasians, emphasizing the clinical significance of understanding CD71′s function and regulation. anti-CD71 antibody (2B6) is an invaluable tool for researchers studying iron metabolism and related disorders.

The preferred CD71/TFRC/Transferrin Receptor antibody is CD71/TFRC/Transferrin Receptor Antibody (3B8 2A1): sc-32272.